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Uncoupling of protease trans-cleavage and helicase activities in pestivirus ns3
期刊论文
Journal of virology, 2017, 卷号: 91, 期号: 21, 页码: 19
作者:
Zheng, Fengwei
;
Lu, Guoliang
;
Li, Ling
;
Gong, Peng
;
Pan, Zishu
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/05/08
Pestivirus
Ns3
Protease
Helicase
Crystal structure
Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3
期刊论文
JOURNAL OF VIROLOGY, 2017, 卷号: 91, 期号: 21
作者:
Zheng, Fengwei
;
Lu, Guoliang
;
Li, Ling
;
Gong, Peng
;
Pan, Zishu
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
pestivirus
NS3
protease
helicase
crystal structure
The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2017, 卷号: 23, 期号: 30, 页码: 4493-4554
作者:
Wang, Shuni
;
Wang, Yibing
;
Wang, Jiang
;
Sato, Tatsunori
;
Izawa, Kunisuke
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Hepatitis C virus (HCV)
pandemic
direct-acting antiviral agents (DAAs)
NS3/4A protease inhibitor
tailor-made amino acids
structure-activity relationship (SAR)
asymmetric synthesis
ring-closing metathesis (RCM)
Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 9, 页码: 1126-1136
作者:
Wu, Deng-wei
;
Mao, Fei
;
Ye, Yan
;
Li, Jian
;
Xu, Chuan-lian
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Dengue virus
antiviral drug
NS2B/NS3 protease
policresulen
molecular docking
molecular modeling
policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 9, 页码: 1126
作者:
Wu Dengwei
;
Mao Fei
;
Ye Yan
;
Li Jian
;
Xu Chuanlian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
SMALL-MOLECULE INHIBITORS
STRUCTURE-BASED DISCOVERY
DRUG-LIKE MOLECULES
DENGUE VIRUS
SERINE-PROTEASE
NS3 PROTEASE
PEPTIDE INHIBITORS
NS2B-NS3 PROTEASE
ACCURATE DOCKING
IN-VITRO
Dengue virus
antiviral drug
NS2B/NS3 protease
policresulen
molecular docking
molecular modeling
Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 8, 页码: 1074-1081
作者:
Yu, Ye
;
Jing, Jing-feng
;
Tong, Xian-kun
;
He, Pei-lan
;
Li, Yuan-chao
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
hepatitis C virus
NS3/4A protease
secreted embryonic alkaline phosphatase (Seap)
2,4-diaminoquinazoline
carboxamide
telaprevir
discoveringnovelantihcvcompoundswithinhibitoryactivitiestowardhcvns34aprotease
期刊论文
actapharmacologicasinica, 2014, 卷号: 35, 期号: 8, 页码: 1074
作者:
Yu Ye
;
Jing Jingfeng
;
Tong Xiankun
;
He Peilan
;
Li Yuanchao
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
HEPATITIS-C VIRUS
PLUS RIBAVIRIN
REPLICATION
TELAPREVIR
POTENT
EPIDEMIOLOGY
BOCEPREVIR
hepatitis C virus
NS3/4A protease
secreted embryonic alkaline phosphatase (Seap)
2,4-diaminoquinazoline
carboxamide
telaprevir
Identification of Novel Small Molecules as Inhibitors of Hepatitis C Virus by Structure-Based Virtual Screening
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 卷号: 14, 期号: 11, 页码: 22845-22856
作者:
Li, Jing
;
Liu, Xian
;
Li, Shanshan
;
Wang, Yulan
;
Zhou, Nannan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
hepatitis C virus (HCV)
NS3
NS4A serine protease
structure-based drug design (SBDD)
virtual screening
Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: A computational study
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 卷号: 1820, 期号: 10, 页码: 1526-1534
作者:
Pan, DB
;
Xue, WW
;
Zhang, WQ
;
Liu, HX
;
Yao, XJ
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/12/29
Hepatitis C virus
NS3/4A protease
Drug resistance
ITMN-191
Molecular dynamics simulation
Molecular modeling study on the resistance mechanism of HCV NS3/4A serine protease mutants R155K, A156V and D168A to TMC435
期刊论文
ANTIVIRAL RESEARCH, 2012, 卷号: 93, 期号: 1
-
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2014/12/05
HCV NS3/4A protease
TMC435
Drug resistance
Substrate envelope
Molecular dynamics simulations
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