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科研机构
合肥物质科学研究院 [12]
北京大学 [2]
安徽大学 [1]
内容类型
期刊论文 [15]
发表日期
2022 [1]
2021 [2]
2020 [1]
2019 [2]
2017 [1]
2016 [5]
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Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2
期刊论文
LEUKEMIA, 2022
作者:
Yang, Jing
;
Weisberg, Ellen L.
;
Qi, Shuang
;
Ni, Wei
;
Mei, Husheng
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2022/02/14
Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
Hu, Chen
;
Zou, Fengming
;
Wang, Aoli
;
Miao, Weili
;
Liang, Qianmao
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/11/01
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia
期刊论文
HAEMATOLOGICA, 2021, 卷号: 106
作者:
Wang, Aoli
;
Hu, Chen
;
Chen, Cheng
;
Liang, Xiaofei
;
Wang, Beilei
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/04/26
Repurposing of Kinase Inhibitors for Treatment of COVID-19
期刊论文
PHARMACEUTICAL RESEARCH, 2020, 卷号: 37
作者:
Weisberg, Ellen
;
Parent, Alexander
;
Yang, Priscilla L.
;
Sattler, Martin
;
Liu, Qingsong
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/10/26
Coronavirus
SARS-CoV-2
SARS-CoV
MERS-CoV
kinase inhibitors
pharmacokinetics
antiviral therapy
COVID-19
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:
Liang, Xiaofei
;
Wang, Beilei
;
Chen, Cheng
;
Wang, Aoli
;
Hu, Chen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/05/21
Discovery of N-phenyl)-2-phenyl)acetamide as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication Mutant Selective Inhibitor for Acute Myeloid Leukemia
期刊论文
Journal of Medicinal Chemistry, 2019, 卷号: Vol.62 No.2, 页码: 875-892
作者:
Tingting Lu
;
Jian Ge
;
Tao Ren
;
Wenchao Wang
;
Junjie Wang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/04/24
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:
Wang, Beilei
;
Deng, Yuanxin
;
Chen, Yongfei
;
Yu, Kailin
;
Wang, Aoli
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2018/08/16
Btk
Kinase Inhibitor
Irreversible Inhibitor
Structure-activity Relationship
B-cell Lymphoma
Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 43, 页码: 69760-69769
作者:
Wang, Aoli
;
Yan, Xiao-E
;
Wu, Hong
;
Wang, Wenchao
;
Hu, Chen
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2017/11/21
Ibrutinib
Egfr Kinase
Dfg-in/c-helix-out
Inactive Conformation
Nsclc
Simultaneous inhibition of Vps34 kinase would enhance PI3K delta inhibitor cytotoxicity in the B-cell malignancies
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 33, 页码: 53515-53525
作者:
Liu, Xiaochuan
;
Wang, Aoli
;
Liang, Xiaofei
;
Liu, Juanjuan
;
Zou, Fengming
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/11/21
Pi3k Delta
Vps34
Combination
Chronic Lymphatic Leukemia
Acute Myeloid Leukemia
Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 22, 页码: 32641-32651
作者:
Liu, Xiaochuan
;
Wang, Aoli
;
Liang, Xiaofei
;
Chen, Cheng
;
Liu, Juanjuan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2017/11/16
Pi3k Delta
Leukemia
B-cell Malignances
Pi3k
Kinase Inhibitors
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