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CORC

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Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent 期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:  Jiang, Zongru;  Wang, Li;  Liu, Xuesong;  Chen, Cheng;  Wang, Beilei
收藏  |  浏览/下载：26/0  |  提交时间：2020/11/26
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:  Liang, Xiaofei;  Jiang, Zongru;  Huang, Zhenghui;  Li, Feng;  Chen, Cheng
收藏  |  浏览/下载：27/0  |  提交时间：2020/11/26
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models 期刊论文
CANCER LETTERS, 2019, 页码: 105-114
作者:  Lu, Tingting;  Chen, Cheng;  Wang, Aoli;  Jiang, Zongru;  Qi, Ziping
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/14
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen
收藏  |  浏览/下载：14/0  |  提交时间：2019/01/11
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming
收藏  |  浏览/下载：66/0  |  提交时间：2019/12/25
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli
收藏  |  浏览/下载：14/0  |  提交时间：2019/12/10
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.
收藏  |  浏览/下载：63/0  |  提交时间：2019/06/10
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: Vol.156, 页码: 831-846
作者:  Zongru Jiang;  Wenliang Wang;  Fengming Zou;  Jing Liu;  Qingsong Liu
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/22
Discovery of -2-amino-N-pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide as a potent and selective phosphoinositide 3-kinase delta inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: Vol.156, 页码: 831-846
作者:  Liu, Xiaochuan;  Jiang, Zongru;  Li, Feng;  Hu, Zhenquan;  Ge, Juan
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/24
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong
收藏  |  浏览/下载：743/0  |  提交时间：2018/07/04

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