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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua
收藏  |  浏览/下载：35/0  |  提交时间：2021/08/17
Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 191, 页码: 8
作者:  Zhang, Mengqi;  Liu, Haiming;  He, Jiajin;  Gui, Yuzhou;  Qian, Hongjie
收藏  |  浏览/下载：31/0  |  提交时间：2020/12/24
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:  Tian, Qian-qian;  Zhu, Yun-ting;  Diao, Xing-xing;  Zhang, Xiang-lei;  Xu, Ye-chun
收藏  |  浏览/下载：69/0  |  提交时间：2020/12/24
细菌环二鸟苷酸( c-di-GMP) 代谢相关基因的研究进展 期刊论文
海岸科学, 2019, 卷号: 6, 期号: 2, 页码: 1-7
作者:  解志红 刘亚楠 孙雨 王艺璇
收藏  |  浏览/下载：4/0  |  提交时间：2021/11/12
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan
收藏  |  浏览/下载：56/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/01
PHOSPHODIESTERASE INHIBITOR TYPE 5 (PDE 5), AND PREPARATION METHOD AND APPLICATION THEREOF 专利
申请日期: 2019-01-03, 公开日期: 2019-01-03
作者:  Lou HX(娄红祥);  Zheng HB(郑泓波);  Sun B(孙斌);  Li L(李琳);  Gao Y(高云)
收藏  |  浏览/下载：4/0  |  提交时间：2020/01/04
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ]
收藏  |  浏览/下载：137/0  |  提交时间：2019/06/28
Effect of phosphodiesterase type 5 inhibitors on prostate cancer risk and biochemical recurrence after prostate cancer treatment: A systematic review and meta-analysis 期刊论文
ANDROLOGIA, 2019, 卷号: 51, 期号: 2
作者:  Hong, Yang;  Wu, Yougen;  Qu, Xiaofeng;  Wang, Yang;  Xia, Ju
收藏  |  浏览/下载：23/0  |  提交时间：2019/12/05
Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth 期刊论文
Oncogene, 2019, 卷号: 38, 页码: 1106-1120
作者:  Zhang Dan-Dan[1];  Li Yue[2];  Xu Yuan[3];  Kim Jaejik[4];  Huang Shuang[5]
收藏  |  浏览/下载：17/0  |  提交时间：2019/04/22

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