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Ratiometric co-delivery of hydroxychloroquine and calculated low-dose paclitaxel efficiently suppresses tumor growth in hepatocellular carcinoma mouse models in vivo 期刊论文
NANO TODAY, 2022, 卷号: 44
作者:  Wang, Wenbin;  Sun, Hui;  Gong, Yan;  Liu, Xiangsheng;  Liu, Xiao
收藏  |  浏览/下载：116/0  |  提交时间：2022/12/23
The safety and efficacy of neoadjuvant PD-1 inhibitor with chemotherapy for locally advanced esophageal squamous cell carcinoma 期刊论文
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2021, 卷号: 12
作者:  Shen, Dijian;  Chen, Qixun;  Wu, Jie;  Li, Jianqiang;  Tao, Kaiyi
收藏  |  浏览/下载：36/0  |  提交时间：2021/04/26
Thermogel Loaded with Low-Dose Paclitaxel as a Facile Coating to Alleviate Periprosthetic Fibrous Capsule Formation 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2018, 卷号: 10, 期号: 36
作者:  Luan, Jiabin;  Zhang, Zheng;  Shen, Wenjia;  Chen, Yipei;  Yang, Xiaowei
收藏  |  浏览/下载：14/0  |  提交时间：2019/12/05
Microneedle-Assisted, DC-Targeted Codelivery of pTRP-2 and Adjuvant of Paclitaxel for Transcutaneous Immunotherapy 期刊论文
SMALL, 2017, 卷号: 13, 期号: 28
作者:  Xu, Jiaojiao;  Xu, Beihua;  Tao, Jin;  Yang, Yunxu;  Hu, Ying
收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08
Vitamin E-rich nanoemulsion enhances the antitumor efficacy of low-dose paclitaxel by driving Th1 immune response and promoting dendritic cell activation 会议论文
JOURNAL OF CONTROLLED RELEASE, 2017-08-10
作者:  Ye, Jun;  Dong, Wujun;  Yang, Yanfang;  Xia, Xuejun;  Jin, Yiqun
收藏  |  浏览/下载：3/0  |  提交时间：2020/01/04
Vitamin E-rich nanoemulsion enhances the antitumor efficacy of low-dose paclitaxel by driving Th1 immune response and promoting dendritic cell activation 期刊论文
2017, 卷号: 259, 页码: E72-E72
作者:  Ye, Jun;  Dong, Wujun;  Yang, Yanfang;  Xia, Xuejun;  Jin, Yiqun
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/04
Vitamin E-rich Nanoemulsion Enhances the Antitumor Efficacy of Low-Dose Paclitaxel by Driving Th1 Immune Response 期刊论文
2017, 卷号: 34, 期号: 6, 页码: 1244-1254
作者:  Ye Jun;  Dong Wujun;  Yang Yanfang;  Hao Huazhen;  Liao Hengfeng
收藏  |  浏览/下载：5/0  |  提交时间：2020/01/04
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  
Low-dose paclitaxel improves the therapeutic efficacy of recombinant adenovirus encoding CCL21 chemokine against murine cancer 期刊论文
CANCER SCIENCE, 2014, 卷号: 105, 期号: 11, 页码: 1393-1401
作者:  Chen, Ping;  Luo, Shan;  Wen, Yan-Jun;  Li, Yu-Hua;  Li, Jiong
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17
Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer 期刊论文
http://dx.doi.org/10.1186/bcr3563, 2013
Wang, Shuiliang; Huang, Jingcao; Lyu, Hui; Cai, Bo; Yang, Xiaoping; Li, Fang; Tan, Jianming; Edgerton, Susan M.; Thor, Ann D.; Lee, Choon-Kee; Liu, Bolin; 王水良; 谭建明
收藏  |  浏览/下载：3/0  |  提交时间：2015/07/22

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