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CORC

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Amygdala dynorphin/kappa opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:  Zan, Gui-ying;  Sun, Xiang;  Wang, Yu-jun;  Liu, Rui;  Wang, Chen-yao
收藏  |  浏览/下载：28/0  |  提交时间：2021/08/17
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:  Huang, Huoming;  Wang, Wenli;  Xu, Xuejun;  Zhu, Chen;  Wang, Yujun
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/01
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui
收藏  |  浏览/下载：93/0  |  提交时间：2020/07/01
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:  An, Xiaoli;  Bai, Qifeng;  Bing, Zhitong;  Zhou, Shuangyan;  Shi, Danfeng
收藏  |  浏览/下载：57/0  |  提交时间：2019/11/10
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a kappa Partial Agonist and mu Partial Agonist 期刊论文
SCIENTIFIC REPORTS, 2018, 卷号: 8
作者:  Wang, Yu-Hua;  Chai, Jing-Rui;  Xu, Xue-Jun;  Ye, Ru-Feng;  Zan, Gui-Ying
收藏  |  浏览/下载：91/0  |  提交时间：2019/01/08
7 beta-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 14, 页码: 4254-4263
作者:  Sun, Hui-jiao;  Wang, Yu-hua;  Yuan, Cong-min;  Kong, Ling-hui;  Xu, Xue-jun
收藏  |  浏览/下载：82/0  |  提交时间：2019/01/08
The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent kappa-Opioid Agonistic Activities 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 4, 页码: 766-776
作者:  Li, Wei;  Long, Jian-Dong;  Qian, Yuan-Yuan;  Long, Yu;  Xu, Xue-Jun
收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08
kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice 期刊论文
NEUROPHARMACOLOGY, 2016, 卷号: 110, 页码: 92-101
作者:  Wang, Yu-Jun;  Hang, Ai;  Lu, Yu-Chen;  Long, Yu;  Zan, Gui-Ying
收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08
Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance 期刊论文
NEUROPHARMACOLOGY, 2016, 卷号: 108, 页码: 364-372
作者:  Wang, ZL;  Li, N;  Wang, P;  Tang, HH;  Han, ZL
收藏  |  浏览/下载：6/0  |  提交时间：2017/01/10
The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel kappa agonist and mu partial agonist, in mice 期刊论文
PSYCHOPHARMACOLOGY, 2016, 卷号: 233, 期号: 12, 页码: 2411-2418
作者:  Wang, Qian;  Long, Yu;  Hang, Ai;  Zan, Gui-Ying;  Shu, Xiao-Hong
收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08

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