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科研机构
海洋研究所 [3]
合肥物质科学研究院 [3]
上海药物研究所 [1]
山东大学 [1]
中南大学 [1]
中国医学科学院 北京... [1]
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期刊论文 [10]
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EGPI-1, a novel eIF4E/eIF4G interaction inhibitor, inhibits lung cancer cell growth and angiogenesis through Ras/MNK/ERK/eIF4E signaling pathway
期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 卷号: 352, 页码: 10
作者:
Qi, Xueju
;
Zhang, Shuna
;
Chen, Zekun
;
Wang, Lijun
;
Zhu, Wenyong
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/07/18
Human lung cancer
eIF4E
EGPI-1
Anticancer
Angiogenesis
Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Li, Qinglin
;
Xia, Liang
;
Sun, Caixing
;
Zhang, Huangjie
;
Zheng, Mengying
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/25
natural product
borneol
malignant glioma
autophagy
HIF-1 alpha
Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 160, 页码: 496-505
作者:
Wang, Jun
;
Wang, Lijun
;
Zhang, Shuhong
;
Fan, Junting
;
Yang, Hui
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2020/10/26
eIF4E/eIF4G
Human lung cancer
Apoptosis
DNA damage
ROS
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:
Chen, Cheng
;
Cheng, Chuan-dong
;
Wu, Hong
;
Wang, Zuo-wei
;
Wang, Li
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
glioblastoma
osimertinib
temozolamide
MAPK-signaling pathway
MNK
eukaryotic translation initiation factor 4E
The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo
期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2020, 卷号: 137, 页码: 10
作者:
Guo, Chuanlong
;
Hou, Yuzhen
;
Yu, Xuemin
;
Zhang, Fan
;
Wu, Xiaochen
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/09/22
Apoptosis
eIF4F
ERK
MNK
A549 cells
Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 735-751
作者:
Jin, Xin
;
Merrett, James
;
Tong, Sheng
;
Flower, Bartholomew
;
Xie, Jianling
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Mnk
eIF4E inhibition
Thieno[2,3-d]pyrimidine
Selective inhibitor
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway
期刊论文
Oncotarget, 2016, 卷号: 7, 期号: 19, 页码: 27787-27801
作者:
Wen, Qiuyuan
;
Wang, Weiyuan
;
Luo, Jiadi
;
Chu, Shuzhou
;
Chen, Lingjiao
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
non-small cell lung cancer (NSCLC)
mTOR
eIF4E
Mnk1
apoptosis
Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia
期刊论文
LEUKEMIA, 2016, 卷号: 30, 期号: 1, 页码: 173-181
作者:
Wu, H.
;
Hu, C.
;
Wang, A.
;
Weisberg, E. L.
;
Chen, Y.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/10/27
The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206
期刊论文
2015, 卷号: 14, 期号: 2, 页码: 232-242
作者:
Wang, Hongtao
;
Huang, Fang
;
Wang, Jian
;
Wang, Peng
;
Lv, Wenjie
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
AKT
eIF4E
eIF4F complex
cap-dependent translation
4EBP1
4EGI-1
mTORC1
mTORC2
eIF4E
eukaryotic translation initiation factor 4E
4EBP1
eIF4E-binding protein 1
p70S6K
ribosomal p70 S6 kinase
mTORC1
mammalian target of rapamycin complex 1
mTORC2 mammalian target of rapamycin complex 2
PI3K
phosphatidylinositol 3-kinase
ER stress
endoplasmic reticulum stress
Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73
期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 17, 页码: 7691-7704
作者:
Lam, Frankie
;
Abbas, Abdullahi Y.
;
Shao, Hao
;
Teo, Theodosia
;
Adams, Julian
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
CDK9
shRNA
Mnks
eIF4E
kinase inhibitors
PI3K/Akt/mTOR
Ras/Raf/MAPK
Flavopiridol
CGP57380
apoptosis
transcription
translation
drug development
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