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Antioxidative and antiapoptotic effects of (+)-clausenamide on acetaminophen-induced nephrotoxicity in mice 期刊论文
2018, 卷号: 1, 期号: 3, 页码: 127
作者:  Hong-Min Yu[1,2];  Min Wang[3];  Zong-Chao Yu[4];  Yi-Fang Li[1,2];  Chun-Xin Huang[3]
收藏  |  浏览/下载:12/0  |  提交时间:2019/12/17
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect 期刊论文
2016, 卷号: 162, 页码: 179-187
作者:  Chu, Shifeng;  Liu, Shaolin;  Duan, Wenzhen;  Cheng, Yong;  Jiang, Xueying
收藏  |  浏览/下载:2/0  |  提交时间:2020/01/04
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:  Chu, Shifeng;  Liu, Shaolin;  Duan, Wenzhen;  Cheng, Yong;  Jiang, Xueying
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/27
Chirality  Clausenamide  Dementia  Long-term potentiation  Signaling pathway  Calcium  6-OHDA  6-hydroxyldopamine  ACE  acetylcholinesterase  ACh  acetylcholine  AD  Alzheimer's disease  AUC0–12 h  0–12 h area under curve  APP  amyloid precursor protein  APV  R-2-amino-5-phosphonopentanoate  AUC0−∝  whole area under curve  BBB  blood–brain barrier  BDNF  brain-derived neurotrophic factor  CaM  calmodulin  CaMKII  calmodulin kinase II  ChAT  choline acetyltransferase  CREB  cAMP responding element binding  CHM  Chinese herbal medicine  clau  clausenamide  CL  clearance  Cmax  maximum concentration  CDK-5  cyclin-dependent kinase-5  DM  diabetes mellitus  DAG  diacylglycerol  ER  endoplasmic reticulum  ERK  extracellular signal-regulated kinases  GSK-3  glycogen synthase kinase-3  IP3  inositol triphosphate  LTP  long term potentiation  MWM  Morris water maze  NGF  nerve growth factor  NMDA  N-Methyl-D-aspartate  D  nNOS  neural nitric oxide synthase  PAT  passive avoidance tasks  Pir  piracetam  PLC  phospholipase C  PP1  phosphate 1  PKC  protein kinase C  tmax  time of peak concentration  t1/2α  absorption half-life  t1/2β  elimination half-life  Tau  microtubule-associated proteins  TCM  traditional Chinese medicine  Vd  apparent volume of distribution  VDCC  voltage-dependent calcium channel  
Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance 期刊论文
2015, 卷号: 98, 期号: 1, 页码: 224-230
作者:  Hua, Fang;  Shi, Mei-jun;  Zhu, Xiao-lu;  Li, Meng;  Wang, Hong-xu
收藏  |  浏览/下载:3/0  |  提交时间:2020/01/04
Stereoselective Regulation of P-gp Activity by Clausenamide Enantiomers in Caco-2, KB/KBv and Brain Microvessel Endothelial Cells 期刊论文
2015, 卷号: 10, 期号: 8, 页码: e0135866
作者:  Zhu, Chuan-jiang;  Hua, Fang;  Zhu, Xiao-lu;  Li, Meng;  Wang, Hong-xu
收藏  |  浏览/下载:12/0  |  提交时间:2020/01/13
Method for preparing optically pure (-)-clausenamide compound 专利
专利类型: 发明, 专利号: 14/125;055, 申请日期: 2014-12-16,
作者:  Shi YA(史一安);  Peng XY(彭先友);  Li PJ(李培军)
收藏  |  浏览/下载:22/0  |  提交时间:2016/06/23
Pharmacokinetics and metabolism of clausenamide enantiomers 期刊论文
2014, 卷号: 28, 期号: 1
作者:  Zhu, Chuan-Jiang;  Zhang, Jun-Tian
收藏  |  浏览/下载:4/0  |  提交时间:2020/01/13
Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action 期刊论文
2014, 卷号: 4, 期号: 6, 页码: 417-423
作者:  Chu, Shi-feng;  Zhang, Jun-tian
收藏  |  浏览/下载:9/0  |  提交时间:2020/01/13
Studies on the synthesis and biological evaluation of the metabolite of clausenamide CM2 and its stereoisomers 期刊论文
2014, 卷号: 74, 页码: 736-741
作者:  Li, XingZhou;  Lai, Kangying;  Wu, Kemei;  Huang, DaoFei;  Huang, Liang
收藏  |  浏览/下载:8/0  |  提交时间:2020/01/13
Novel Concise Synthesis of (-)-Clausenamide 期刊论文
2013, 卷号: 31, 期号: 3, 页码: 344-348
作者:  Liu, Di;  Yu, Xiaoming;  Huang, Liang
收藏  |  浏览/下载:3/0  |  提交时间:2020/01/13


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