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中国医学科学院 北... [15]
化学研究所 [3]
上海药物研究所 [2]
暨南大学 [1]
湖南中医药大学 [1]
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期刊论文 [20]
专利 [1]
会议论文 [1]
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2018 [1]
2016 [2]
2015 [2]
2014 [4]
2013 [2]
2012 [4]
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Antioxidative and antiapoptotic effects of (+)-clausenamide on acetaminophen-induced nephrotoxicity in mice
期刊论文
2018, 卷号: 1, 期号: 3, 页码: 127
作者:
Hong-Min Yu[1,2]
;
Min Wang[3]
;
Zong-Chao Yu[4]
;
Yi-Fang Li[1,2]
;
Chun-Xin Huang[3]
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/17
(+)-黄皮酰胺
对乙酰氨基酚
肾损伤
氧化应激
凋亡通路
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/04
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/27
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
6-OHDA
6-hydroxyldopamine
ACE
acetylcholinesterase
ACh
acetylcholine
AD
Alzheimer's disease
AUC0–12 h
0–12 h area under curve
APP
amyloid precursor protein
APV
R-2-amino-5-phosphonopentanoate
AUC0−∝
whole area under curve
BBB
blood–brain barrier
BDNF
brain-derived neurotrophic factor
CaM
calmodulin
CaMKII
calmodulin kinase II
ChAT
choline acetyltransferase
CREB
cAMP responding element binding
CHM
Chinese herbal medicine
clau
clausenamide
CL
clearance
Cmax
maximum concentration
CDK-5
cyclin-dependent kinase-5
DM
diabetes mellitus
DAG
diacylglycerol
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinases
GSK-3
glycogen synthase kinase-3
IP3
inositol triphosphate
LTP
long term potentiation
MWM
Morris water maze
NGF
nerve growth factor
NMDA
N-Methyl-D-aspartate
D
nNOS
neural nitric oxide synthase
PAT
passive avoidance tasks
Pir
piracetam
PLC
phospholipase C
PP1
phosphate 1
PKC
protein kinase C
tmax
time of peak concentration
t1/2α
absorption half-life
t1/2β
elimination half-life
Tau
microtubule-associated proteins
TCM
traditional Chinese medicine
Vd
apparent volume of distribution
VDCC
voltage-dependent calcium channel
Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance
期刊论文
2015, 卷号: 98, 期号: 1, 页码: 224-230
作者:
Hua, Fang
;
Shi, Mei-jun
;
Zhu, Xiao-lu
;
Li, Meng
;
Wang, Hong-xu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/04
Clausenamide
Enantiomers
Cytochrome P450 3A4
P-glycoprotein
Caco-2 cell line
Stereoselective Regulation of P-gp Activity by Clausenamide Enantiomers in Caco-2, KB/KBv and Brain Microvessel Endothelial Cells
期刊论文
2015, 卷号: 10, 期号: 8, 页码: e0135866
作者:
Zhu, Chuan-jiang
;
Hua, Fang
;
Zhu, Xiao-lu
;
Li, Meng
;
Wang, Hong-xu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/01/13
Method for preparing optically pure (-)-clausenamide compound
专利
专利类型: 发明, 专利号: 14/125;055, 申请日期: 2014-12-16,
作者:
Shi YA(史一安)
;
Peng XY(彭先友)
;
Li PJ(李培军)
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2016/06/23
Pharmacokinetics and metabolism of clausenamide enantiomers
期刊论文
2014, 卷号: 28, 期号: 1
作者:
Zhu, Chuan-Jiang
;
Zhang, Jun-Tian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/13
Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action
期刊论文
2014, 卷号: 4, 期号: 6, 页码: 417-423
作者:
Chu, Shi-feng
;
Zhang, Jun-tian
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/13
(-)Clausenamide
Enantiomers
Cognition
Alzheimer's disease pathology
Tau
High phosphorylation
Synaptic plasticity
Studies on the synthesis and biological evaluation of the metabolite of clausenamide CM2 and its stereoisomers
期刊论文
2014, 卷号: 74, 页码: 736-741
作者:
Li, XingZhou
;
Lai, Kangying
;
Wu, Kemei
;
Huang, DaoFei
;
Huang, Liang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/13
Nootropic agents
Metabolite
Clausenamide
Long-term potentiation
Novel Concise Synthesis of (-)-Clausenamide
期刊论文
2013, 卷号: 31, 期号: 3, 页码: 344-348
作者:
Liu, Di
;
Yu, Xiaoming
;
Huang, Liang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/13
()-clausenamide
diastereoselective synthesis
Ireland-Claisen rearrangement
diastereoselective bromolactonization
bromo--lactone aminolysis
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