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浏览/检索结果: 共1条，第1-1条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Silver nanoparticles cause complications in pregnant mice 期刊论文 International Journal of Nanomedicine, 2015, 卷号: 10, 期号: 1, 页码: 7057-7071 作者:  Zhang, Xi-Feng;  Park, Jung-Hyun;  Choi, Yun-Jung;  Kang, Min-Hee;  Gurunathan, Sangiliyandi* 收藏  |  浏览/下载：1/0  |  提交时间：2019/12/27 The synthesis of AgNPs was performed using culture extracts of Bacillus cereus. The synthesized AgNPs were characterized by X-ray diffraction  Fourier transform infrared spectroscopy  and transmission electron microscopy. AgNPs were administrated into pregnant mice via intravenous infusion at 1.0 mg/kg doses at 6.5 days postcoitum (dpc). At 13.5  and 17.5 dpc  the pregnant mice were euthanized  and the embryo and placenta were isolated. The meiotic status of oocytes was evaluated. DNA methylation studies were performed  and aberrant imprinting disrupted fetal  placental  and postnatal development. Quantitative real-time polymerase chain reaction analysis and Western blot were used to analyze various gene expressions.