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CORC

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Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite 期刊论文
FRONTIERS IN PHYSIOLOGY, 2018, 卷号: 9, 页码: 1025
作者:  Li N(李宁);  Wang CZ(王成之);  Sun SJ(孙树津);  Zhang C(张晨);  Lv DY(吕东媛)
收藏  |  浏览/下载：47/0  |  提交时间：2018/10/19
Changes in tension regulates proliferation and migration of fibroblasts by remodeling expression of ECM proteins 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 卷号: 12, 期号: 3, 页码: 1542-1550
作者:  Jiang MM;  Qiu JH;  Zhang LL;  Lu DY;  Long M(龙勉)
收藏  |  浏览/下载：19/0  |  提交时间：2016/12/08
GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-beta-Induced Smad3 Phosphorylation 期刊论文
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 卷号: 26, 期号: 8, 页码: 1827-1838
作者:  Ai, Jun;  Nie, Jing;  He, Jiangbo;  Guo, Qin;  Li, Mei
收藏  |  浏览/下载：27/0  |  提交时间：2016/01/19
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  
Screening and Isolation for Anti-hepatofibrotic Components from Medicinal Mushrooms using TGF-beta 1-induced Live Fibrosis in Hepatic Stellate Cells 期刊论文
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS, 2014, 卷号: 16, 期号: 6, 页码: 529-539
作者:  Geng, Yan;  Wang, Jing;  Xie, Minfeng;  Lu, Zhen-Ming;  Xu, Hong-Yu
收藏  |  浏览/下载：31/0  |  提交时间：2016/06/23
The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 卷号: 422, 期号: 1, 页码: 139-145
作者:  Han MJ;  Wang HL;  Zhang HT;  Han ZZ[*]
收藏  |  浏览/下载：14/0  |  提交时间：2012/09/13
ADAM15 suppresses cell motility by driving integrin alpha 5 beta 1 cell surface expression via Erk inactivation 期刊论文
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 卷号: 40, 期号: 10, 页码: 2164-2173
作者:  Chen, Qin;  Meng, Ling-hua;  Zhu, Cai-hua;  Lin, Li-ping;  Lu, He
收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08

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