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科研机构
上海药物研究所 [2]
湖南农业大学 [1]
湖南大学 [1]
内容类型
期刊论文 [4]
发表日期
2018 [2]
2017 [1]
2014 [1]
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Proteomics analysis reveals a potential new target protein for the lipid-lowering effect of Berberine8998
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 9, 页码: 1473-1482
作者:
Yu, Cheng-yin
;
Liu, Gang-yi
;
Liu, Xiao-hui
;
Gui, Yu-zhou
;
Liu, Hai-ming
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
berberine
berberine8998
proteomics
lipid-lowering
cholesterol
triglycerides
LDL-C
fatty acid metabolism
hypercholesterolemia
obesity
proteomicsanalysisrevealsapotentialnewtargetproteinforthelipidloweringeffectofberberine8998
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 9, 页码: 1473
作者:
u Chengyin
;
Liu Gangyi
;
Liu Xiaohui
;
Gui Yuzhou
;
Liu Haiming
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
DISEASE
ATHEROSCLEROSIS
IDENTIFICATION
CHALLENGES
EFFICACY
RECEPTOR
berberine
berberine8998
proteomics
lipid-lowering
cholesterol
triglycerides
LDL-C
fatty acid metabolism
hypercholesterolemia
obesity
Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High-Fat Diet.
期刊论文
J Biol Chem, 2017, 卷号: Vol.292 No.9, 页码: 3800-3809
作者:
Zeng, Jia
;
Deng, Senwen
;
Wang, Yiping
;
Li, Ping
;
Tang, Lian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/31
acetyl
coenzyme
A
(acetyl-CoA)
fatty
acid
fatty
acid
metabolism
fatty
acid
oxidation
inhibitor
metabolism
Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice
期刊论文
Journal of Hepatology, 2014, 卷号: 60, 期号: 5, 页码: 1046-1054
作者:
Zhu, Li-Hua
;
Wang, Aibing
;
Luo, Pengcheng
;
Wang, Xinan
;
Jiang, Ding-Sheng
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/23
IR
insulin resistance
WT
wild type
KO
knockout
TG
transgenic
NTG
non-transgenic
NC
normal chow
HFD
high-fat diet
PPARα
peroxisome proliferator-activated receptor alpha
ECM
extracellular matrix
NL
normal liver
NAFLD
non-alcoholic fatty liver disease
H&E
hematoxylin and eosin
ALT
alanine transaminase
AST
aspartate transaminase
ALP
alkaline phosphatase
HMGCR
3-hydroxy-3-methyl-glutaryl-CoA reductase
LDL
low density lipoprotein
HDL
high density lipoprotein
LDLR
low-density lipoprotein receptor
GPAT
glycerol-3-phosphate acyltransferase
DGAT
diglyceride acyltransferase
FFA
free fatty acid
SREBP1c
sterol response element binding protein 1c
ACC
acetyl-CoA carboxylase
FAS
fatty acid synthase
SCD
stearoyl-CoA desaturase
LXR-α
liver X receptor-α
ARG-1
arginase-1
ABCA
ATP-binding cassette transporter A
ABCG
ATP-binding cassette transporter G
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
AMPK
AMP-activated protein kinase
IL
interleukin
TNF-α
tumor necrosis factor alpha
MCP-1
monocyte chemoattractant protein 1
MRC1
mannose receptor, C type 1
MGL
macrophage galactose-type C-type lectin
JNK
Jun N-terminal kinase
FBG
fasting glucose
HOMA-IR
homeostasis model assessment of insulin resistance
GTT
glucose tolerance test
ITT
intraperitoneal insulin tolerance test
Fins
fasting insulin
shRNA
short hairpin RNA
GFP
green fluorescent protein
IRS
insulin receptor substrate
Akt
protein kinase B
HSL
hormone sensitive lipase
ATGL
adipose triacylglycerol lipase
ACOX
acyl-coenzyme A oxidase
CPT-1α
carnitine palmitoyltransferase-1-α
LCAD
long-chain acyl-CoA dehydrogenase
MCAD
medium-chain acyl-CoA dehydrogenase
UCP
uncoupling protein
FGF21
fibroblast growth factor
PPRE
peroxisome proliferators response element
AUC
area under the curve
IKKβ
inhibitor of nuclear factor kappa B kinase beta subunit
Spondin 2
Fatty liver
Insulin resistance
PPARα
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