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上海药物研究所 [7]
吉林大学白求恩第一医... [2]
山东大学 [1]
复旦大学上海医学院 [1]
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期刊论文 [10]
会议论文 [1]
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Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Zheng, Yuan-dong
;
Zhang, Hua
;
Zhan, Yan
;
Bian, Yi-cong
;
Ma, Sheng
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/05/24
vicagrel
[C-14]vicagrel
vicagrel pharmacokinetics
vicagrel metabolism
mass balance
P2Y(12) receptor inhibitor
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127, 页码: 151-160
作者:
Li, Cai
;
Zhang, Yifan
;
Chen, Weili
;
Lu, Youming
;
Li, Wei
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
Vicagrel
Clopidogrel
P2Y(12) inhibitor
Pharmacokinetics
Active metabolite
Thienopyridine
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127
作者:
Liu, Cai
;
Zhang, Yifan
;
Chen, Weili
;
Lu, Youming
;
Li, Wei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/12/05
Vicagrel
Clopidogrel
P2Y(12) inhibitor
Pharmacokinetics
Active metabolite
Thienopyridine
Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Li, Xiaojiao
;
Liu, Ca
;
Zhu, Xiaoxue
;
Wei, Haijing
;
Zhang, Hong
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2019/01/08
vicagrel
pharmacokinetics
pharmacodynamics
safety
clopidogrel
Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 149, 页码: 394-402
作者:
Liu, Cai
;
Lu, Youming
;
Sun, Hongbin
;
Yang, Jin
;
Liu, Yongqiang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Vicagrel
Clopidogrel
Active metabolite
LC-MS/MS
Human plasma
P2Y(12) inhibitor
Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Li, Xiaojiao
;
Liu, Ca
;
Zhu, Xiaoxue
;
Wei, Haijing
;
Zhang, Hong
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/05
vicagrel
pharmacokinetics
pharmacodynamics
safety
clopidogrel
Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans
期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:
Jiang, Jinfang
;
Chen, Xiaoyan
;
Zhong, Dafang
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
arylacetamide deacetylase
vicagrel
clopidogrel
hydrolytic metabolism
METABOLISM AND PHARMACOKINETICS OF VICAGREL, A NOVEL THIENOPYRIDINE P2Y12 INHIBITOR, COMPARED WITH CLOPIDOGREL IN HEALTHY CHINESE SUBJECTS
会议论文
作者:
Liu, Cai
;
Chen, Xiaoyan
;
Zhong, Dafang
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  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration
期刊论文
MOLECULES, 2016, 卷号: 21, 期号: 6
作者:
Xu, Xueyu
;
Zhao, Xue
;
Yang, Zhichao
;
Wang, Hao
;
Meng, Xiangjun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/05
deuteration
clopidogrel
vicagrel
prodrug
active metabolite
antiplatelet agent
Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel
期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 10, 页码: 1632-1641
作者:
Liu, Cai
;
Chen, Zhaoqiang
;
Zhong, Kan
;
Li, Liang
;
Zhu, Weiliang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
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