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科研机构
上海药物研究所 [5]
厦门大学 [2]
山东大学 [2]
上海营养与健康研究所 [2]
中国医学科学院 北京... [1]
长春应用化学研究所 [1]
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期刊论文 [12]
学位论文 [1]
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2021 [1]
2019 [1]
2017 [1]
2014 [2]
2013 [2]
2011 [1]
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Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Henagliflozin, a Novel Selective Inhibitor of Sodium-Glucose Cotransporter 2, in Healthy Subjects Following Single- and Multiple-dose Administration
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 2, 页码: 396-409
作者:
Zhang, Yi-fan
;
Liu, Yan-mei
;
Yu, Chen
;
Wang, Ya-ting
;
Zhan, Yan
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/05/24
diabetes
henagliflozin
pharmacodynamics
pharmacokinetics
SGLT-2 inhibitors
Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 398-416
作者:
Wang, Yibing
;
Lou, Yang
;
Wang, Jiang
;
Li, Dan
;
Chen, Hui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
SGLT2 inhibitors
Diabetes
Sugar modification
Structure-activity relationship
Urinary glucose excretion
Oral glucose tolerance
A Model-based Meta-analysis Study on the Quantitative Relationship of Pharmacokinetics: Fasting Plasma Glucose corrected Urinary Glucose Excretion-HbA1c for Sodium Glucose co-Transporter-2 Inhibitors in T2DM Patients
期刊论文
2017, 卷号: 44, 页码: S11-S11
作者:
Zhou, Jiawei
;
Ren, Yupeng
;
Liu, Dongyang
;
Hu, Bei
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  |  
浏览/下载:5/0
  |  
提交时间:2020/01/04
SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 613-624
作者:
Yan, Pang-ke
;
Zhang, Li-na
;
Feng, Ying
;
Qu, Hui
;
Qin, Li
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  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
sodium glucose cotransporter 2 (SGLT2)
SHR3824
dapagliflozin
type 2 diabetes mellitus
blood glucose
insulin sensitivity
beta-cell function
Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgf beta 1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice
期刊论文
http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.811, 2014
Wei, Jie
;
Zhang, Ye
;
Luo, Yu
;
Wang, Zhen
;
Bi, Shulin
;
Song, Dan
;
Dai, Yuan
;
Wang, Tao
;
Qiu, Longxin
;
Wen, Longping
;
Yuan, Li
;
Yang, James Y.
;
魏杰
;
王涛
;
袁立
;
杨朝勇
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2015/07/22
INDUCED OXIDATIVE STRESS
ALPHA-LIPOIC ACID
MESENCHYMAL TRANSITION
ANTIOXIDATIVE DEFENSE
TARGETING ZEB1
MIR-200 FAMILY
CANCER CELLS
E-CADHERIN
NEPHROPATHY
PATHWAY
Design,synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors
期刊论文
Chinese Chemical Letters, 2013, 期号: 05, 页码: 429-432
作者:
Shuo Zhang
;
Yu-Li Wang
;
Qun-Chao Wei
;
Wei-Ren Xu
;
Li-Da Tang
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  |  
浏览/下载:8/0
  |  
提交时间:2019/12/23
Synthesis
C-Glucoside
SGLT2 inhibitor
Urinary glucose excretion
Cyclohexane-bearing
Design, synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors
期刊论文
中国化学快报, 2013, 卷号: 24, 期号: 5, 页码: 429-432
作者:
Zhang, Shuo
;
Wang, Yu-Li
;
Wei, Qun-Chao
;
Xu, Wei-Ren
;
Tang, Li-Da
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
Synthesis
C-Glucoside
SGLT2 inhibitor
Urinary glucose excretion
Cyclohexane-bearing
Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice
期刊论文
http://dx.doi.org/10.1007/s00125-011-2045-4, 2011
Liu, H.
;
Luo, Y.
;
Zhang, T.
;
Zhang, Y.
;
Wu, Q.
;
Yuan, L.
;
Chung, S. S. M.
;
Oates, P. J.
;
Yang, J. Y.
;
吴乔
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2013/12/12
PROTEIN-KINASE-C
DINUCLEOTIDE REPEAT POLYMORPHISM
HUMAN MESANGIAL CELLS
GROWTH-FACTOR-BETA
OXIDATIVE STRESS
KIDNEY-DISEASE
POLYOL PATHWAY
SORBITOL PATHWAY
HIGH-GLUCOSE
RAT-KIDNEY
无权访问的条目
学位论文
作者:
潘安
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  |  
浏览/下载:10/0
  |  
提交时间:2015/10/10
Metabolic profiling studies on the toxicological effects of realgar in rats by H-1 NMR spectroscopy
期刊论文
toxicology and applied pharmacology, 2009, 卷号: 234, 期号: 3, 页码: 314-325
Wei L
;
Liao PQ
;
Wu HF
;
Li XJ
;
Pei FK
;
Li WS
;
Wu YJ
收藏
  |  
浏览/下载:162/14
  |  
提交时间:2010/06/18
ACUTE PROMYELOCYTIC LEUKEMIA
ARSENIC TRIOXIDE AS2O3
MAGNETIC-RESONANCE SPECTROSCOPY
NMR-SPECTROSCOPY
INDUCED HEPATOTOXICITY
PATTERN-RECOGNITION
METABONOMICS
PLASMA
URINE
CELLS
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