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Metabolic Profiling of Nuciferine in Vivo and in Vitro
期刊论文
Journal of Agricultural and Food Chemistry, 2020, 卷号: 68, 期号: 48, 页码: 14135-14147
作者:
Gao, Hua
;
Zhang, Lei
;
Zhu, An
;
Liu, Xiaoyan
;
Wang, Tianxia
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2022/02/17
Biomolecules
Enzymes
Mammals
Mass spectrometry
Metabolites
Broad spectrum
Drug formulations
High resolution mass spectrometry
Metabolic characteristics
Metabolic profiling
Molecular docking
Nelumbo nucifera
Recombinant enzymes
Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases
期刊论文
ENVIRONMENTAL POLLUTION, 2019, 卷号: 254, 页码: -
作者:
Liu, Yong-Zhe
;
Zhang, Zhi-Peng
;
Fu, Zhi-Wei
;
Yang, Kun
;
Ding, Ning
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  |  
浏览/下载:13/0
  |  
提交时间:2020/09/10
Per- and polyfluoroalkyl substances (PFASs)
UDP-Glucuronosyltransferases (UGTs)
Half inhibition concentration (IC50)
Inhibition type
Inhibition kinetic parameters (Ki)
In vitro-in vivo extrapolation (IVIVE)
Epigenetic regulation of UDP-Glucuronosyltransferase by microRNA-200a/-183: implications for responses to sorafenib treatment in patients with hepatocellular carcinoma
期刊论文
CANCER LETTERS, 2019, 卷号: 454, 页码: 14-25
作者:
Ge, Yang
;
Chen, Shuzhen
;
Mu, Wei
;
Ba, Qian
;
Li, Jingquan
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  |  
浏览/下载:39/0
  |  
提交时间:2019/12/11
HCC
UGT1A9
miR-200a/-183
Sorafenib response
New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9
期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 卷号: 122, 期号: 4, 页码: 424-428
作者:
Xiao, Ling
;
Zhu, Liangliang
;
Li, Wenjuan
;
Li, Conghu
;
Cao, Yunfeng
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  |  
浏览/下载:28/0
  |  
提交时间:2019/06/20
Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases
期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2018, 卷号: 284, 页码: 48-55
作者:
Lv, Xia
;
Zhang, Jian-Bin
;
Wang, Xin-Xin
;
Hu, Wen-Zhong
;
Shi, Yu-Sheng
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  |  
浏览/下载:35/0
  |  
提交时间:2019/06/20
Amentoflavone
Udp-glucuronosyltransferases
Broad-spectrum Inhibitor
Herb-drug Interactions (Hdis)
New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9
期刊论文
Basic & clinical pharmacology & toxicology, 2018, 卷号: 122, 页码: 424-428
作者:
Xiao Ling[1]
;
Zhu Liangliang[2]
;
Li Wenjuan[3]
;
Li Conghu[4]
;
Cao Yunfeng[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/24
Glucuronidation
SN-38
UGT1A1
UGT1A9
Identification of human UDP-glucuronosyltransferase isoforms involved in the isofraxidin glucuronidation and assessment of the species differences of the reaction
期刊论文
FITOTERAPIA, 2017, 卷号: 117, 页码: 118-125
作者:
Meng, Fanxing
;
Li, Yan
;
He, Guiyuan
;
Ge, Guangbo
;
Liu, Shumin
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  |  
浏览/下载:17/0
  |  
提交时间:2019/06/20
Isofraxidin
Udp-glucuronosyltransferases (Ugts)
Human Liver Microsomes (Hlm)
Human Intestinal Microsomes (Him)
Species Differences
Effects of UGT1A9 genetic polymorphisms on monohydroxylated derivative of oxcarbazepine concentrations and oxcarbazepine monotherapeutic efficacy in Chinese patients with epilepsy
期刊论文
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2017, 卷号: 73, 期号: 3
作者:
Lu, Yao
;
Fang, Youxin
;
Wu, Xunyi
;
Ma, Chunlai
;
Wang, Yue
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Epilepsy
Oxcarbazepine
MHD
UGT1A9
Genetic polymorphism
Therapeutic efficacy
Human UDP-Glucuronosyltransferases 1A1, 1A3, 1A9, 2B4 and 2B7 are Inhibited by Diethylstilbestrol
期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2016, 卷号: 119, 期号: 5, 页码: 505-511
作者:
Xiao, Ling
;
Zhu, Liangliang
;
Li, Wenjuan
;
Zhang, Yuan
;
Han, Wenwen
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/06/20
Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2016, 卷号: 301, 页码: 42-49
作者:
Lv, Xia
;
Wang, Xin-Xin
;
Hou, Jie
;
Fang, Zhong-Ze
;
Wu, Jing-Jing
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/06/20
Udp-glucosyltransferases
Entacapone
Tolcapone
Inhibitory Effects
Drug-drug Interactions (Ddi)
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