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科研机构
上海药物研究所 [15]
水生生物研究所 [1]
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期刊论文 [16]
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2021 [2]
2018 [2]
2017 [1]
2016 [1]
2015 [2]
2014 [3]
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Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
18 beta-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 12, 页码: 1865-1873
作者:
Wu, Shou-yan
;
Cui, Shi-chao
;
Wang, Le
;
Zhang, Yi-ying
;
Yan, Xiao-xia
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
hepatoprotective effect
cholestatic liver injury
18 beta-glycyrrhetinic acid (18b-GA)
FXR
Sirt1
bile acid transporters
The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine
期刊论文
XENOBIOTICA, 2018, 卷号: 48, 期号: 3, 页码: 314-323
作者:
Xiao, Ling
;
Xue, Yaru
;
Zhang, Cuifeng
;
Wang, Le
;
Lin, Yunfei
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
Berberine
MATE1
hepatobiliary distribution
excretion
DDIs
Nimesulide and 4 '-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis
期刊论文
DRUG METABOLISM AND DISPOSITION, 2017, 卷号: 45, 期号: 5, 页码: 441-448
作者:
Zhou, Lei
;
Pang, Xiaoyan
;
Jiang, Jingfang
;
Zhong, Dafang
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Optimized Hepatocyte-Like Cells with Functional Drug Transporters Directly-Reprogrammed from Mouse Fibroblasts and their Potential in Drug Disposition and Toxicology
期刊论文
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 卷号: 38, 期号: 5, 页码: 1815-1830
作者:
Wu, Zhi-Tao
;
Yao, Dan
;
Ji, Shu-Yi
;
Ni, Xuan
;
Gao, Yi-Meng
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Direct reprogramming
Hepatocyte-like cells
Hepatic transporters
Biliary clearances
Cholestasis
Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury
期刊论文
Drug metabolism and disposition: the biological fate of chemicals, 2015, 卷号: 43, 期号: 11, 页码: 1751-9
作者:
Li, Xiuli
;
Zhong, Kan
;
Guo, Zitao
;
Zhong, Dafang
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
The Hepatobiliary Disposition of Timosaponin B2 Is Highly Dependent on Influx/Efflux Transporters but Not Metabolism
期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 1, 页码: 63-72
作者:
Sheng, Jingjing
;
Tian, Xiaoting
;
Xu, Guanglin
;
Wu, Zhitao
;
Chen, Chen
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/01/08
Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 9, 页码: 1188-1198
作者:
Wu, Zhi-tao
;
Qi, Xin-ming
;
Sheng, Jing-jing
;
Ma, Lei-lei
;
Ni, Xuan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
timosaponin A3
hepatotoxicity
cholestasis
bile acid
transporter
Cyp7a1
ROS
N-acetyl-L-cysteine
mangiferin
Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 卷号: 724, 页码: 185-192
作者:
He, Lei
;
Yang, Yuan
;
Guo, Cen
;
Yao, Dan
;
Liu, Hui-hui
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Diabetes
Sandwich cultured rat hepatocytes
Breast cancer resistant protein
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