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浏览/检索结果:
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Hepatoprotective Mechanism and Material Basis of Swertia Plants Based On Network Pharmacology and Molecular Docking Method
期刊论文
LATIN AMERICAN JOURNAL OF PHARMACY, 2023, 卷号: 42, 期号: 2, 页码: 374
作者:
Huang, Xian-Ju
;
Liu, Shi-Quan
;
Dai, Jia-Wei
;
LI, Tian-Cai
;
Wu, Zhou-Yang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2023/12/01
Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2021
作者:
Cai, Lei
;
Chen, Yong
;
Tong, Xiaoling
;
Wu, Xue
;
Bao, Hua
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2021/06/15
EGFR
ERBB2
gene fusions
tyrosine kinase inhibitors
young lung cancer patients
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 9
作者:
Gu, Dongyan
;
Cheng, Gang
;
Zhang, Mengmeng
;
Zhou, Yu-Bo
;
Li, Jia
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/05/24
PI3K alpha inhibitors
Virtual screening
2-(5-(quinolin-6-yl)-1,3,4 oxadiazol-2-yl)acetamide
Molecular dynamics
Immune microenvironment features and efficacy of PD-1/PD-L1 blockade in non-small cell lung cancer patients with EGFR or HER2 exon 20 insertions
期刊论文
THORACIC CANCER, 2020
作者:
Chen, Kaiyan
;
Pan, Guoqiang
;
Cheng, Guoping
;
Zhang, Fanrong
;
Xu, Yanjun
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/12/28
EGFR
HER2
immunotherapy
NSCLC
PD‐
L1
Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation
期刊论文
ONCOGENE, 2020, 卷号: 39
作者:
Jin, Ying
;
Bao, Hua
;
Le, Xiuning
;
Fan, Xiaojun
;
Tang, Ming
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/11/26
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA(H1047R) accompanied with pro-tumorigenic secretome
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 817-829
作者:
Liu, Xue-Ling
;
Liu, Jia-Li
;
Xu, Yi-Chao
;
Zhang, Xi
;
Wang, Yu-Xiang
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  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
PI3K alpha
membrane metallo-endopeptidase
senescence
macrophage
breast cancer
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China
期刊论文
CANCER MANAGEMENT AND RESEARCH, 2019, 卷号: 11, 页码: 1473-1492
作者:
Lin, Wenchu
;
Wu, Haibo
;
Wang, Wei
;
Du, Jun
;
Li, Hong
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/06/20
breast cancer
PIK3CA
clinicopathological characteristics
prognosis
High-throughput barcode screening elucidates the functional characteristics and mutual relevance of PIK3CA and PIK3R1 somatic mutations in Chinese patients with breast cancer
会议论文
作者:
Chen, L.
;
Yang, L.
;
Hu, X.
;
Shao, Z.
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Somatic alterations of TP53, ERBB2, PIK3CA and CCND1 are associated with chemosensitivity for breast cancers
期刊论文
CANCER SCIENCE, 2019, 卷号: 110, 期号: 4
作者:
Yang, Libo
;
Ye, Feng
;
Bao, Longlong
;
Zhou, Xiaoyan
;
Wang, Zhe
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2019/12/05
breast neoplasm
genetic variation
high-throughput nucleotide sequencing
neoadjuvant therapy
pathologic complete response
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