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CORC

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Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:  Zheng, Yuan-dong;  Zhang, Hua;  Zhan, Yan;  Bian, Yi-cong;  Ma, Sheng
收藏  |  浏览/下载：44/0  |  提交时间：2021/05/24
Update of P2Y receptor pharmacology: IUPHAR Review 27 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 11, 页码: 2413-2433
作者:  Jacobson, Kenneth A.;  Delicado, Esmerilda G.;  Gachet, Christian;  Kennedy, Charles;  von Kuegelgen, Ivar
收藏  |  浏览/下载：61/0  |  提交时间：2020/07/01
Optimization of P2Y(12) Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbarnoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3088-3106
作者:  Kong, Deyu;  Xue, Tao;  Guo, Bin;  Cheng, Jianjun;  Liu, Shunyin
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127, 页码: 151-160
作者:  Li, Cai;  Zhang, Yifan;  Chen, Weili;  Lu, Youming;  Li, Wei
收藏  |  浏览/下载：102/0  |  提交时间：2019/01/08
Chinese patients carrying two CYP2C19 LOFs have a more active state of P2Y(12)-G(i) signaling and larger MPV in post-clopidogrel platelets with acute coronary syndrome 期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 卷号: 12, 期号: 7
作者:  Xu, Huajie;  Wu, Hongyi;  Zhao, Xin;  Zhang, Yan;  Chen, She
收藏  |  浏览/下载：18/0  |  提交时间：2019/12/05
CYP2C19  clopidogrel  P2Y(12)  VASP  Akt  MPV  
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127
作者:  Liu, Cai;  Zhang, Yifan;  Chen, Weili;  Lu, Youming;  Li, Wei
收藏  |  浏览/下载：26/0  |  提交时间：2019/12/05
P2Y(12) deficiency in mouse impairs noradrenergic system in brain, and alters anxiety-like neurobehavior and memory 期刊论文
GENES BRAIN AND BEHAVIOR, 2019, 卷号: 18, 期号: 2
作者:  Zheng, F.;  Zhou, Q.;  Cao, Y.;  Shi, H.;  Wu, H.
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis 期刊论文
CLINICAL CANCER RESEARCH, 2019, 卷号: 25, 页码: 1318-1330
作者:  Hu, Li-Peng;  Zhang, Xiao-Xin;  Jiang, Shu-Heng;  Tao, Ling-Ye;  Li, Qing
收藏  |  浏览/下载：31/0  |  提交时间：2019/12/02
adenosine triphosphate  ar c118925xx  gemcitabine  glucose transporter 1  hypoxia inducible factor 1alpha  Myc protein  platelet derived growth factor beta receptor  platelet derived growth factor receptor  protein kinase Yes  purinergic P2Y receptor antagonist  purinergic P2Y2 receptor  unclassified drug  Yes1 protein, Akt signaling  animal experiment  animal model  animal tissue  Article  cancer inhibition  cancer prognosis  cancer staging  controlled study  drug potentiation  glycolysis  human  human cell  human tissue  inflammation  lymph node metastasis  male  mouse  mouse model  nonhuman  overall survival  pancreas adenocarcinoma  pancreatic ductal carcinoma cell line  Pi3K/Akt signaling  priority journal  RNA sequence  tumor classification  tumor differentiation  tumor microenvironment  tumor volume  tumor xenograft  
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y(1) receptor antagonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 302-310
作者:  Peng, Jingjing;  Zhao, Lifen;  Wang, Lanlan;  Chen, Hui;  Qiu, Yunguang
收藏  |  浏览/下载：47/0  |  提交时间：2019/01/08
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 18, 页码: 8136-8154
作者:  Baqi, Younis;  Pillaiyar, Thanigaimalai;  Abdelrahman, Aliaa;  Kaufmann, Olesja;  Aishaibani, Samer
收藏  |  浏览/下载：105/0  |  提交时间：2019/01/08

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