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科研机构
上海药物研究所 [13]
北京大学 [10]
兰州大学 [3]
武汉病毒研究所 [3]
武汉大学 [2]
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期刊论文 [35]
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Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 卷号: 821, 页码: 11-20
作者:
Yao, Xingang
;
Ling, Yun
;
Guo, Songxin
;
He, Shijun
;
Wang, Jinan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
DENV2
Acorus tatarinowii Schott
Diasarone-I
2'O
methyltransferase
GP205, a new hepatitis C virus NS3/4A protease inhibitor, displays higher metabolic stability in vitro and drug exposure in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11
作者:
Zhai, Pei-bin
;
Qing, Jie
;
Li, Ben
;
Zhang, Lin-qi
;
Ma, Lan
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
HCV
NS3/4A
direct acting antiviral therapy
GP205
sofosbuvir
daclatasvir
Uncoupling of protease trans-cleavage and helicase activities in pestivirus ns3
期刊论文
Journal of virology, 2017, 卷号: 91, 期号: 21, 页码: 19
作者:
Zheng, Fengwei
;
Lu, Guoliang
;
Li, Ling
;
Gong, Peng
;
Pan, Zishu
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/05/08
Pestivirus
Ns3
Protease
Helicase
Crystal structure
Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3
期刊论文
JOURNAL OF VIROLOGY, 2017, 卷号: 91, 期号: 21
作者:
Zheng, Fengwei
;
Lu, Guoliang
;
Li, Ling
;
Gong, Peng
;
Pan, Zishu
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
pestivirus
NS3
protease
helicase
crystal structure
The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2017, 卷号: 23, 期号: 30, 页码: 4493-4554
作者:
Wang, Shuni
;
Wang, Yibing
;
Wang, Jiang
;
Sato, Tatsunori
;
Izawa, Kunisuke
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  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Hepatitis C virus (HCV)
pandemic
direct-acting antiviral agents (DAAs)
NS3/4A protease inhibitor
tailor-made amino acids
structure-activity relationship (SAR)
asymmetric synthesis
ring-closing metathesis (RCM)
Tailor-Made alpha-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA)
期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 期号: 16, 页码: 2757-2774
作者:
Sato, Tatsunori
;
Izawa, Kunisuke
;
Luis Acena, Jose
;
Liu, Hong
;
Soloshonok, Vadim A.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Asymmetric synthesis
Amino acids
Medicinal chemistry
Drug design
Antiviral agents
Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base
期刊论文
AMINO ACIDS, 2016, 卷号: 48, 期号: 4, 页码: 973-986
作者:
Kawashima, Aki
;
Shu, Shuangjie
;
Takeda, Ryosuke
;
Kawamura, Akie
;
Sato, Tatsunori
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
Anti-viral (HCV) activity
Asymmetric synthesis
Amino acids
Chirality
Schiff bases
Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 9, 页码: 1126-1136
作者:
Wu, Deng-wei
;
Mao, Fei
;
Ye, Yan
;
Li, Jian
;
Xu, Chuan-lian
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Dengue virus
antiviral drug
NS2B/NS3 protease
policresulen
molecular docking
molecular modeling
Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro
期刊论文
Bioorganic and medicinal chemistry, 2015, 卷号: 23, 期号: 17, 页码: 5539-5545
作者:
Shi, Fangyuan
;
Zhang, Yingjie
;
Xu, Wenfang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
HCV
Protease inhibitors
Peptidomimetics
Triazole
Acylsulfonamide
policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 9, 页码: 1126
作者:
Wu Dengwei
;
Mao Fei
;
Ye Yan
;
Li Jian
;
Xu Chuanlian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
SMALL-MOLECULE INHIBITORS
STRUCTURE-BASED DISCOVERY
DRUG-LIKE MOLECULES
DENGUE VIRUS
SERINE-PROTEASE
NS3 PROTEASE
PEPTIDE INHIBITORS
NS2B-NS3 PROTEASE
ACCURATE DOCKING
IN-VITRO
Dengue virus
antiviral drug
NS2B/NS3 protease
policresulen
molecular docking
molecular modeling
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