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科研机构
上海药物研究所 [9]
新疆理化技术研究所 [1]
昆明植物研究所 [1]
合肥物质科学研究院 [1]
内容类型
期刊论文 [12]
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2022 [1]
2021 [3]
2020 [1]
2019 [3]
2018 [1]
2017 [1]
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Oncology [1]
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Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235
作者:
Qu, Bingxue
;
Xu, Yongjin
;
Lu, Yang
;
Zhuang, Weihao
;
Jin, Xinxin
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2022/12/23
XPO1
Multiple myeloma
MM.1S
N-phenylsulfonamide
Oral administration
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 13
作者:
Wang, Yuhong
;
Mi, Tian
;
Li, Yiming
;
Kan, Weijuan
;
Xu, Gaoya
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Lenalidomide
Multiple myeloma
MM.1S
Late-stage sulfuration
Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 14
作者:
Zhao, Yanmei
;
Xu, Lei
;
Zhang, Jiankang
;
Zhang, Mengmeng
;
Lu, Jingyi
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Proteasome inhibitor
Piperidine
Peptidyl
Anti-cancer
SAR
Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction
期刊论文
ARCHIV DER PHARMAZIE, 2020, 页码: 10
作者:
Xiao, Donghuai
;
Wang, Yu-jie
;
Wang, Han-lin
;
Zhou, Yu-bo
;
Li, Jia
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  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
antitumor
arylboronic acid
lenalidomide
Suzuki cross-coupling
Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 18, 页码: 8642-8663
作者:
Hu, Jianping
;
Tian, Chang-Qing
;
Damaneh, Mohammadali Soleimani
;
Li, Yanlian
;
Cao, Danyan
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 176, 页码: 419-430
作者:
Xiao, Donghuai
;
Wang, Yu-jie
;
Hu, Xiao-bei
;
Kan, Wei-juan
;
Zhang, Qiumeng
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Lenalidomide
Thioether
Anti-Tumor
Structural modification
A Near-Complete Series of Four Atropisomeric Jozimine A(2)-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2019, 卷号: 82, 期号: 11, 页码: 3033-3046
作者:
Fayez, S (Fayez, Shaimaa)[ 1,2 ]
;
Li, J (Li, Jun)[ 1,3,4 ]
;
Feineis, D (Feineis, Doris)[ 1 ]
;
Assi, LA (Assi, Laurent Ake)[ 5 ]
;
Kaiser, M (Kaiser, Marcel)[ 6,7 ]
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/01/10
Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 页码: 156-175
作者:
Hu, Jianping
;
Wang, Yingqing
;
Li, Yanlian
;
Cao, Danyan
;
Xu, Lin
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
BRD4
BI2536
Indoline
WPF binders
c-Myc
PD-L1
Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 176-195
作者:
Hu, Jianping
;
Wang, Yingqing
;
Li, Yanlian
;
Xu, Lin
;
Cao, Danyan
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
BRD4 inhibitor
Kinase
BI-2536
Dihydroquinoxalin-2(1H)-one
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