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北京大学 [9]
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期刊论文 [18]
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DrugSpaceX: a large screenable and synthetically tractable database extending drug space
期刊论文
NUCLEIC ACIDS RESEARCH, 2021, 卷号: 49, 期号: D1, 页码: D1170-D1178
作者:
Yang, Tianbiao
;
Li, Zhaojun
;
Chen, Yingjia
;
Feng, Dan
;
Wang, Guangchao
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2021/05/24
A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts
期刊论文
ACS CENTRAL SCIENCE, 2020, 卷号: 6, 期号: 2, 页码: 213-225
作者:
Zhang, Bingjie
;
Zhao, Simeng
;
Yang, Dehua
;
Wu, Yiran
;
Xin, Ye
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 17
作者:
Li, Fei
;
Wan, Xiaozhe
;
Xing, Jing
;
Tan, Xiaoqin
;
Li, Xutong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
deep neural network
virtual screening
methyltransferase
epigenetic
drug design
Counting on natural products for drug design
期刊论文
NATURE CHEMISTRY, 2016, 卷号: 8, 期号: 6, 页码: 531-541
Rodrigues, T
;
Reker, D
;
Schneider, P
;
Schneider, G
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  |  
浏览/下载:26/0
  |  
提交时间:2017/01/12
CATALYTIC ENANTIOSELECTIVE SYNTHESIS
INSPIRED COMPOUND COLLECTION
DIVERSITY-ORIENTED SYNTHESIS
RELEVANT CHEMICAL SPACE
TARGET PREDICTION
MACROMOLECULAR TARGETS
COMBINATORIAL LIBRARY
NETWORK PHARMACOLOGY
MEDICINAL CHEMISTRY
LIGAND DISCOVERY
Expression and crystallographic studies of the Arabidopsis thaliana GDP-D-mannose pyrophosphorylase VTC1
期刊论文
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2016, 卷号: 72
作者:
Zhao, Shun
;
Liu, Lin
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  |  
浏览/下载:0/0
  |  
提交时间:2022/07/05
ascorbic acid biosynthesis
GDP-D-mannose pyrophosphorylase
Arabidopsis thaliana
Expression and crystallographic studies of the Arabidopsis thaliana GDP-D-mannose pyrophosphorylase VTC1
期刊论文
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2016, 卷号: 72, 页码: 795-798
作者:
Zhao, Shun
;
Liu, Lin
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2022/07/08
ascorbic acid biosynthesis
GDP-D-mannose pyrophosphorylase
Arabidopsis thaliana
全氟化合物与脂肪酸靶蛋白的相互作用及干扰效应研究
学位论文
博士, 北京: 中国科学院研究生院, 2014
张连营
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  |  
浏览/下载:173/0
  |  
提交时间:2015/06/16
全氟化合物
肝脏型脂肪酸结合蛋白
过氧化物酶体增殖剂激活受体
G-蛋白偶联受体40
信号通路
perfluorinated compounds
liver fatty acid binding protein
peroxisome proliferator-activated receptor γ
G protein coupled receptor 40
signaling pathway.
In silico search for multi- target therapies for osteoarthritis based on 10 common Huoxue Huayu herbs and potential applications to other diseases
期刊论文
molecular medicine reports, 2014
Zheng, Chun-Song
;
Zhuang, Zhi-Qiang
;
Xu, Xiao-Jie
;
Ye, Jin-Xia
;
Ye, Hong-Zhi
;
Li, Xi-Hai
;
Wu, Guang-Wen
;
Xu, Hui-Feng
;
Liu, Xian-Xiang
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/11/16
osteoarthritis
multi-target therapy
Huoxue Huayu herbs
computational simulation
DRUG DISCOVERY
PROLIFERATION
INFLAMMATION
INHIBITION
MEDICINES
NETWORKS
DATABASE
PATHWAY
Computational approaches for exploring the potential synergy and polypharmacology of Duhuo Jisheng Decoction in the therapy of osteoarthritis
期刊论文
molecular medicine reports, 2013
Zheng, Chun-Song
;
Xu, Xiao-Jie
;
Ye, Hong-Zhi
;
Wu, Guang-Wen
;
Li, Xi-Hai
;
Huang, Su-Ping
;
Liu, Xian-Xiang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2015/11/16
Duhuo Jisheng Decoction
osteoarthritis
chemical space
virtual screening
network analysis
polypharmacology
TRADITIONAL CHINESE MEDICINE
DRUG DISCOVERY
NETWORK
VISUALIZATION
BIOLOGY
RISK
ACID
Network pharmacology-based prediction of the multi-target capabilities of the compounds in Taohong Siwu decoction, and their application in osteoarthritis
期刊论文
experimental and therapeutic medicine, 2013
Zheng, Chun-Song
;
Xu, Xiao-Jie
;
Ye, Hong-Zhi
;
Wu, Guang-Wen
;
Li, Xi-Hai
;
Xu, Hui-Feng
;
Liu, Xian-Xiang
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2015/11/16
Taohong Siwu decoction
osteoarthritis
multi-target
network pharmacology
TRADITIONAL CHINESE MEDICINE
DRUG DISCOVERY
POLYPHARMACOLOGY
COMPONENTS
DATABASE
DISEASE
CELLS
MODEL
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