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Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis
期刊论文
CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 12
作者:
Liao, Min
;
Dong, Qiongye
;
Chen, Ruiqing
;
Xu, Liqian
;
Jiang, Yuxuan
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/12/01
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 4, 页码: 589-603
作者:
Liu, Xiaoqi
;
Hu, Yuanyuan
;
Gao, Anhui
;
Xu, Meng
;
Gao, Lixin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
3-Aryl-4-indolyl-maleimides
IDH1/R132H inhibitors
Tumor 2-HG
Synthesis
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis
期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 11
作者:
Liu, Tangjingjun
;
Xia, Lei
;
Yao, Yao
;
Yan, Chen
;
Fan, Yanhua
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  |  
浏览/下载:73/0
  |  
提交时间:2019/04/15
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:
Lin, Xin
;
Tian, Dongsong
;
Fu, Yanhui
;
Li, Yanan
;
Huang, Liejun
收藏
  |  
浏览/下载:143/0
  |  
提交时间:2019/03/18
Polycyclic polyprenylated acylphloroglucinol
Chemical transformation
Cytotoxicity
Cell apoptosis
Cell cycle arrest
Natural gypenosides: targeting cancer through different molecular pathways
期刊论文
CANCER MANAGEMENT AND RESEARCH, 2019, 卷号: 11, 页码: 2287-2297
作者:
Ahmad, Bashir
;
Khan, Suliman
;
Nabi, Ghulam
;
Gamallat, Yaser
;
Su, Pengyu
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  |  
浏览/下载:74/0
  |  
提交时间:2019/06/11
cancer
surgery
chemotherapy
radiation therapy
Gyp
oral
lung
leukemic
colorectal
hepatocellular
Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 1, 页码: 16
作者:
Hu, Jing
;
Li, Xingren
;
Tian, Weifeng
;
Lu, Yanting
;
Xu, Yuhui
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  |  
浏览/下载:66/0
  |  
提交时间:2019/03/18
adenanthin
adipogenesis
reactive oxygen species
obesity
3T3-L1
The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT/mTOR pathway
期刊论文
The International Journal of Biochemistry & Cell Biology, 2019, 卷号: Vol.106, 页码: 8-20
作者:
Yong Guo
;
Yi Li
;
Fang-Fang Wang
;
Bing Xiang
;
Xiao-Ou Huang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/02/28
Acute
leukemia
p53
AKT/mTOR
Nutlin-3
Tanshinone
IIA
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407
作者:
Lu, Wenchao
;
Xiong, Huan
;
Chen, Yu
;
Wang, Chen
;
Zhang, Hao
收藏
  |  
浏览/下载:139/0
  |  
提交时间:2019/01/08
Drug discovery
Epigenetics
Histone acetyltransferase
P300/CBP
Anti-Leukemia Activity of Hyaluronic Acid Coated Silver Nanoparticles for Selective Targeting to Leukemic Cells
期刊论文
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2018, 卷号: Vol.8 No.6, 页码: 906-910
作者:
Zhang, Jian
;
He, Chuan
;
Fei, Xiaofan
;
Xu, Ting
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  |  
浏览/下载:3/0
  |  
提交时间:2019/02/28
Leukemia
Silver-Gold Nanoparticles
Cytotoxicity
Reactive Oxygen Species
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