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湖南中医药大学 [4]
北京大学 [3]
湖南农业大学 [3]
昆明植物研究所 [2]
中南大学 [2]
湖南大学 [1]
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期刊论文 [16]
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Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain
期刊论文
Toxins, 2018, 卷号: 10, 期号: 2, 页码: 64
作者:
Mingqiang Rong
;
Juan Huang
;
Ren Lai
;
Xiongzhi Zeng
;
Bo Chen
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2018/09/29
Peptide Toxin
Sodium Channels
Nav1.7
Pain
Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2016, 卷号: 14, 期号: 9, 页码: 661-670
作者:
Yao Hui-Min
;
Wang Gan
;
Liu Ya-Ping
;
Rong Ming-Qiang
;
Shen Chuan-Bin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2017/01/05
Schizophyllum commune
Sodium channel
Phenolic acids
Painf
A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds
期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:
Rong, Mingqiang
;
Liu, Jiangxin
;
Zhang, Meilin
;
Wang, Gan
;
Zhao, Gang
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2016/09/28
Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels
期刊论文
Toxicon, 2016, 卷号: 111, 期号: Volume 111, 页码: 13-21
作者:
Tao, Huai*
;
Chen, Xia
;
Lu, Min
;
Wu, Yuanyuan
;
Deng, Meichun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
Jingzhaotoxin-I
Voltage-gated sodium channels
Inactivation
Mutation
JZTX
Jingzhaotoxin
VGSCs
voltage-gated sodium channels
TTX
tetrodotoxin
ICK
inhibitor cystine knot
RP-HPLC
reverse-phase high pressure liquid chromatography
MALDI-TOF
matrix assisted laser desorption/ionization time-of-flight
IC50
half-maximal inhibitory concentration
WT
wide type
Inhibition Effects of Tarantula Toxin JZTX-III on Sodium Channel Subtype Nav1.8
期刊论文
Life Science Research, 2016, 卷号: Vol.20 No.3, 页码: 196-201
作者:
Tao Huai
;
Zhang Yiya
;
Chen Xia
;
He Yingchun
;
Liang Songping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/31
Nav1.8
Jingzhaotoxin-Ⅲ (JZTX-Ⅲ)
sodium channel
Nav1.8
analysis of pharmacological activity
ND7/23 cell
patch-clamp
Interaction site for the inhibition of tarantula Jingzhaotoxin-XI on voltage-gated potassium channel Kv2.1
期刊论文
Toxicon, 2016, 卷号: 124, 页码: 8-14
作者:
Tao, Huai*(陶怀)
;
Chen, Xia
;
Deng, Meichun
;
Xiao, Yucheng
;
Wu, Yuanyuan
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/27
Jingzhaotoxin-XI
Kv2.1
Mutation
Molecular determinant
JZTX-XI
Jingzhaotoxin-XI
HPLC
ion-exchange high-pressure liquid chromatography
RP-HPLC
reverse-phase HPLC
MALDI-TOF
matrix assisted laser desorption/ionization time-of-flight
WT
Wide Type
IC50
median inhibitory concentration
Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels
期刊论文
Toxicon, 2016, 卷号: 111, 期号: Volume 111, 页码: 13-21
作者:
Tao, Huai*(陶怀)
;
Chen, Xia
;
Lu, Min
;
Wu, Yuanyuan
;
Deng, Meichun
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/27
Jingzhaotoxin-I
Voltage-gated sodium channels
Inactivation
Mutation
JZTX
Jingzhaotoxin
VGSCs
voltage-gated sodium channels
TTX
tetrodotoxin
ICK
inhibitor cystine knot
RP-HPLC
reverse-phase high pressure liquid chromatography
MALDI-TOF
matrix assisted laser desorption/ionization time-of-flight
IC50
half-maximal inhibitory concentration
WT
wide type
Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II
期刊论文
Peptides, 2015, 卷号: 68, 页码: 175-182
作者:
Huang, Ying
;
Zhou, Xi(周曦)
;
Tang, Cheng
;
Zhang, Yunxiao
;
Tao, Huai(陶怀)
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/27
Jingzhaotoxin-II
Nav1.5
Action mechanism
Analysis of the interaction of tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) with the voltage sensor of Kv2.1 Uncovers the molecular basis for cross-activities on Kv2.1 and Nav1.5 channels
期刊论文
Biochemistry, 2013, 卷号: 52, 期号: 42, 页码: 7439-7448
作者:
Tao, Huai
;
Chen, Jin J
;
Xiao, Yu C
;
Wu, Yuan Y
;
Su, Hai B
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Analysis of the interaction of tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) with the voltage sensor of Kv2.1 Uncovers the molecular basis for cross-activities on Kv2.1 and Nav1.5 channels
期刊论文
Biochemistry, 2013, 卷号: 52, 期号: 42, 页码: 7439-7448
作者:
Tao, Huai
;
Chen, Jin J
;
Xiao, Yu C
;
Wu, Yuan Y
;
Su, Hai B
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
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