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Discovery of a novel jellyfish venom metalloproteinase inhibitor from secondary metabolites isolated from jellyfish-derived fungus Aspergillus versicolor SmT07
期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 卷号: 365, 页码: 8
作者:
Yue, Yang
;
Yu, Huahua
;
Suo, Qishan
;
Li, Rongfeng
;
Liu, Song
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/01/04
Nemopilema nomurai
Jellyfish envenomations
Aspergillus versicolor
Metalloproteinase inhibitors
Molecular docking
Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Structural basis of staphylococcal Stl inhibition on a eukaryotic dUTPase
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 卷号: 184, 页码: 821-830
作者:
Wang, Fang
;
Liu, Changshui
;
Wang, Chongyang
;
Wang, Yan
;
Zang, Kun
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  |  
浏览/下载:31/0
  |  
提交时间:2021/09/18
Stl dUTPase interactions
Proteinaceous inhibitor
Crystal structure
Identification and mechanistic analysis of an inhibitor of the CorC Mg2+ transporter
期刊论文
ISCIENCE, 2021, 卷号: 24, 期号: 4, 页码: 38
作者:
Huang, Yichen
;
Mu, Kaijie
;
Teng, Xinyu
;
Zhao, Yimeng
;
Funato, Yosuke
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/08/17
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
期刊论文
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021, 页码: 21
作者:
Yin, Wanchao
;
Luan, Xiaodong
;
Li, Zhihai
;
Zhou, Ziwei
;
Wang, Qingxing
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  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
A pentapeptide enabled AL3810 liposome-based glioma-targeted therapy with immune opsonic effect attenuated
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 1, 页码: 283-299
作者:
Li, Jinyang
;
Lu, Jiasheng
;
Guo, Haiyan
;
Zhou, Jianfen
;
Wang, Songli
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
Liposome
mn
c(RGDyK)
Immune opsonization
Immunogenicity
Anti-glioma efficacy
Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 19, 页码: 10972-10983
作者:
Ma, Yuqin
;
Luo, Qichao
;
Fu, Jie
;
Che, Yanxin
;
Guo, Fei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/05/24
Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation
期刊论文
FRONTIERS IN PHARMACOLOGY, 2020, 卷号: 11, 页码: 9
作者:
Yang, Longhe
;
Ji, Chunyan
;
Li, Yitian
;
Hu, Fan
;
Zhang, Fang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/10
NAAA inhibitor
atractylodin
>
anti-inflammation
microglia
traditional Chinese medicine
USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines
期刊论文
FEBS JOURNAL, 2020, 页码: 18
作者:
Wang, Hui
;
Meng, Qian
;
Ding, Yiluan
;
Xiong, Muya
;
Zhu, Mengying
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  |  
浏览/下载:84/0
  |  
提交时间:2020/12/24
colorectal cancer
HDX-MS
inhibitor
USP25
USP28
Vismodegib
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