CORC

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CORC

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Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125
作者:  Zhang, Huimin;  He, Jixiao;  Hu, Guang;  Zhu, Fei;  Jiang, Hao
收藏  |  浏览/下载：36/0  |  提交时间：2022/01/04
Structures of full-length glycoprotein hormone receptor signalling complexes 期刊论文
NATURE, 2021, 页码: 24
作者:  Duan, Jia;  Xu, Peiyu;  Cheng, Xi;  Mao, Chunyou;  Croll, Tristan
收藏  |  浏览/下载：53/0  |  提交时间：2021/11/04
Mechanochemical Activation of Class-B G-Protein-Coupled Receptor upon Peptide-Ligand Binding 期刊论文
NANO LETTERS, 2020, 卷号: 20, 期号: 7, 页码: 5575-5582
作者:  Lo Giudice, Cristina;  Zhang, Haonan;  Wu, Beili;  Alsteens, David
收藏  |  浏览/下载：18/0  |  提交时间：2020/12/24
Full-length human GLP-1 receptor structure without orthosteric ligands 期刊论文
naturecommunications, 2020, 卷号: 11, 期号: 1, 页码: 1
作者:  Fan Wu;  Linlin Yang;  Kaini Hang;  Mette Laursen;  Lijie Wu
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:  An, Xiaoli;  Bai, Qifeng;  Bing, Zhitong;  Zhou, Shuangyan;  Shi, Danfeng
收藏  |  浏览/下载：57/0  |  提交时间：2019/11/10
Dimerization and Conformational Exchanges of the Receiver Domain of Response Regulator PhoB from Escherichia coli 期刊论文
JOURNAL OF PHYSICAL CHEMISTRY B, 2018, 卷号: 122, 期号: 22, 页码: 5749-5757
作者:  Liu, Yixiang;  Li, Conggang;  Liu, Maili;  Jiang, Ling;  Kou, Xinhui
收藏  |  浏览/下载：24/0  |  提交时间：2018/08/15
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.
收藏  |  浏览/下载：62/0  |  提交时间：2019/06/10
Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism 期刊论文
BIOCHEMICAL JOURNAL, 2018, 卷号: 475, 期号: -, 页码: 2209-2224
作者:  Li, PP;  Xu, DQ;  Ma, TQ;  Wang, DY;  Li, WD
收藏  |  浏览/下载：24/0  |  提交时间：2019/12/17
Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 24, 页码: 9865-9881
作者:  Yin, Yanting;  de Waal, Parker W.;  He, Yuanzheng;  Zhao, Li-Hua;  Yang, Dehua
收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08

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