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科研机构
昆明植物研究所 [6]
北京大学 [1]
大连理工大学 [1]
暨南大学 [1]
昆明医科大学 [1]
内容类型
期刊论文 [10]
发表日期
2019 [2]
2018 [2]
2016 [1]
2015 [3]
2011 [2]
学科主题
Chemistry,... [1]
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Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions
期刊论文
THROMBOSIS AND HAEMOSTASIS, 2019, 卷号: 119, 期号: 5, 页码: 705-715
作者:
Xiao, Chuang
;
Zhao, Longyan
;
Gao, Na
;
Wu, Mingyi
;
Zhao, Jinhua
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/06/24
nonasaccharide from fucosylated glycosaminoglycan
intrinsic factor Xase complex
factor IXa
anticoagulant
Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions
期刊论文
THROMBOSIS AND HAEMOSTASIS, 2019, 卷号: 119, 期号: 5
作者:
Xiao, Chuang
;
Zhao, Longyan
;
Gao, Na
;
Wu, Mingyi
;
Zhao, Jinhua
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/12/04
nonasaccharide from fucosylated glycosaminoglycan
intrinsic factor Xase complex
factor IXa
anticoagulant
Synthesis of Fucosylated Chondroitin Sulfate Nonasaccharide as a Novel Anticoagulant Targeting Intrinsic Factor Xase Complex
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 卷号: 57, 期号: 39, 页码: 12880-12885
作者:
Zhang, Xiao
;
Liu, Huiying
;
Lin, Lisha
;
Yao, Wang
;
Zhao, Jinhua
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2018/10/22
Anticoagulants
Drug Discovery
Fucosylated Chondroitin Sulfate
Glycosaminoglycans
Oligosaccharides
Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 133-143
作者:
Xu, Li
;
Gao, Na
;
Xiao, Chuang
;
Lin, Lisha
;
Purcell, Steven W.
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  |  
浏览/下载:26/0
  |  
提交时间:2019/03/29
Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors
期刊论文
THROMBOSIS RESEARCH, 2016, 卷号: 146, 页码: 59-68
作者:
Xiao, Chuang
;
Lian, Wu
;
Zhou, Lutan
;
Gao, Na
;
Xua, Li
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2017/01/05
Fucosylated glycosaminoglycan
coagulation proteases
biolayer interferometry
binding kinetics
structure-activity relationship
Discovery of an intrinsic tenase complex inhibitor: Pure nonasaccharide from fucosylated glycosaminoglycan
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 卷号: 112, 期号: 27, 页码: 8284-8289
作者:
Zhao, Longyan
;
Wu, Mingyi
;
Xiao, Chuang
;
Yang, Lian
;
Zhou, Lutan
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2015/12/17
anticoagulant
inhibitors
oligosaccharides
carbohydrates
drug discovery
Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 92, 页码: 257-269
作者:
Wu, Mingyi
;
Wen, Dandan
;
Gao, Na
;
Xiao, Chuang
;
Yang, Lian
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2015/06/29
Fucosylated chondroitin sulfate
Factor Xase inhibitor
Anticoagulant
Antithrombotic
Structure-activity relationship
Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives
期刊论文
2015, 卷号: 9, 页码: 1743
作者:
Gao, Jia-Suo[1]
;
Tong, Xu-Peng[2]
;
Chang, Yi-Qun[1]
;
He, Yu-Xuan[1]
;
Mei, Yu-Dan[1]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/10
A Network-Based Multi-Target Computational Estimation Scheme for Anticoagulant Activities of Compounds
期刊论文
plos one, 2011
Li, Qian
;
Li, Xudong
;
Li, Canghai
;
Chen, Lirong
;
Song, Jun
;
Tang, Yalin
;
Xu, Xiaojie
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/13
CRYSTAL-STRUCTURE
FACTOR XA
3-DIMENSIONAL STRUCTURE
THROMBIN INHIBITORS
DRUG-THERAPY
FACTOR IXA
BINDING
DESIGN
PERFORMANCE
DISCOVERY
Investigation on the binding mode of benzothiophene analogues as potent factor IXa (FIXa) inhibitors in thrombosis by CoMFA, docking and molecular dynamic studies
期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2011, 卷号: 26, 页码: 792-804
作者:
Hao, Ming
;
Li, Yan
;
Zhang, Shu-Wei
;
Yang, Wei
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/18
FIXa
benzothiophene
docking
CoMFA
MD
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