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科研机构
上海药物研究所 [6]
厦门大学 [1]
北京大学 [1]
大连理工大学 [1]
合肥物质科学研究院 [1]
内容类型
期刊论文 [10]
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2020 [2]
2018 [1]
2017 [2]
2013 [1]
2011 [1]
2010 [1]
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ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle
期刊论文
PLOS BIOLOGY, 2020, 卷号: 18
作者:
Li, Zhiyuan
;
Tian, Xiaofei
;
Ji, Xinmiao
;
Wang, Junjun
;
Chen, Hanxiao
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/10/29
A novel phosphoramide compound, DCZ0847, displays in vitro and in vivo anti-myeloma activity, alone or in combination with bortezomib
期刊论文
CANCER LETTERS, 2020, 卷号: 478, 页码: 45-55
作者:
Chen, Gege
;
Hu, Ke
;
Sun, Haiguo
;
Zhou, Jinfeng
;
Song, Dongliang
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2020/07/01
Multiple myeloma
Bone marrow microenvironment
DNA damage
JAK2/STAT3 pathway
DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 7, 页码: 643-650
作者:
Xiao, Wenqin
;
Li, Bo
;
Sun, Xi
;
Yu, Dandan
;
Xie, Yongsheng
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
DCZ3301
T-cell leukemia/lymphoma
apoptosis
cell cycle
PI3K/AKT
Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336
作者:
Fu, Yan
;
Tang, Shuai
;
Su, Yi
;
Lan, Xiaojing
;
Ye, Yan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Cyclin-dependent kinase
CDK inhibitor
Structure-activity relationship
In vitro and in vivo profiling
Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma
期刊论文
THERANOSTICS, 2017, 卷号: 7, 期号: 15, 页码: 3690-3699
作者:
Gao, Minjie
;
Li, Bo
;
Sun, Xi
;
Zhou, Yunfei
;
Wang, Yingcong
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
Multiple Myeloma
DCZ3301
antitumor activities
synergistic cytotoxicity
Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase
期刊论文
http://dx.doi.org/10.1242/jcs.132845, 2013
Yu, Zhi-yong
;
Zhang, Meng-ting
;
Wang, Gao-yuan
;
Xu, Dan
;
Keifenheim, Daniel
;
Franco, Alejandro
;
Cansado, Jose
;
Masuda, Hirohisa
;
Rhind, Nick
;
Wang, Yamei
;
Jin, Quan-wen
;
王亚梅
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2015/07/22
DNA-DAMAGE CHECKPOINT
SEPTATION INITIATION NETWORK
CYCLIN-DEPENDENT KINASE
ANAPHASE-PROMOTING COMPLEX
CELL-CYCLE
SCHIZOSACCHAROMYCES-POMBE
MITOTIC EXIT
M-PHASE
TYROSINE PHOSPHORYLATION
SACCHAROMYCES-CEREVISIAE
Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest
期刊论文
investigational new drugs, 2011
Fu, Jia-ning
;
Li, Jing
;
Tan, Qiang
;
Yin, Han-wei
;
Xiong, Kun
;
Wang, Tian-yu
;
Ren, Xiao-yuan
;
Zeng, Hui-hui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/10
Ethaselen
Cisplatin
Combination index
Cell cycle regulation
LoVo
DNA-DAMAGE
QUANTITATIVE-ANALYSIS
INDUCED CYTOTOXICITY
POSSIBLE INVOLVEMENT
CYCLE
APOPTOSIS
P53
MECHANISM
GROWTH
UCN-01
B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest
期刊论文
INVESTIGATIONAL NEW DRUGS, 2010, 卷号: 28, 期号: 1, 页码: 26-34
作者:
Xiong, Xishan
;
Zhang, Yingwei
;
Gao, Xiang
;
Dong, Zheyi
;
Li, Lin
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Pyrrole-substituted indolinone
Cell cycle arrest
Cyclin-dependent kinase
Cdc2
Cyclin B1
LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation
期刊论文
ACTA PHARMACOLOGICA SINICA, 2009, 卷号: 30, 期号: 9, 页码: 1359-1368
作者:
Zhou, Yu-bo
;
Feng, Xu
;
Wang, Li-na
;
Du, Jun-qing
;
Zhou, Yue-yang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
LGH00031
ortho-quinone
CDC25B
irreversible inhibitor
ROS
Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 卷号: 16, 页码: 7127-7132
作者:
Zhang, Shixuan
;
Ma, Jigang
;
Bao, Yongming
;
Yang, Puwen
;
Zou, Liang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/27
flavonoid analogues
baicalein
CDK1/cyclin B inhibitor
SAR
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