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Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer 期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:  Wang, Xin;  Pei, Gang
收藏  |  浏览/下载:25/0  |  提交时间:2019/04/28
Defining the minimum substrate and charge recognition model of gamma-secretase 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424
作者:  Yan, Yan;  Xu, Ting-Hai;  Melcher, Karsten;  Xu, H. Eric
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma - secretase cleavage sites 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 38, 页码: 15826-15837
作者:  Yan, Yan;  Xu, Ting-Hai;  Harikumar, Kaleeckal G.;  Miller, Laurence J.;  Melcher, Karsten
收藏  |  浏览/下载:17/0  |  提交时间:2019/01/08
Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance 期刊论文
Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:  Guo, Xiao-dan;  Sun, Guang-long;  Zhou, Ting-ting;  Xu, Xin;  Zhu, Zhi-yuan
收藏  |  浏览/下载:37/0  |  提交时间:2019/05/09
Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid beta production and clearance 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:  Guo, Xiao-dan;  Sun, Guang-long;  Zhou, Ting-ting;  Xu, Xin;  Zhu, Zhi-yuan
收藏  |  浏览/下载:14/0  |  提交时间:2019/01/08
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio 期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:  Xu, Ting-Hai;  Yan, Yan;  Kang, Yanyong;  Jiang, Yi;  Melcher, Karsten
收藏  |  浏览/下载:21/0  |  提交时间:2019/01/08
Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 卷号: 112, 期号: 11, 页码: 3344-3349
作者:  Dang, SY;  Wu, SJ;  Wang, JW;  Li, HB;  Huang, M
收藏  |  浏览/下载:18/0  |  提交时间:2015/07/22
Trafficking regulation of proteins in Alzheimer's disease 期刊论文
http://dx.doi.org/10.1186/1750-1326-9-6, 2014
Jiang, Shangtong; Li, Yanfang; Zhang, Xian; Bu, Guojun; Xu, Huaxi; Zhang, Yun-wu; 卜国军; 许华曦; 张云武
收藏  |  浏览/下载:3/0  |  提交时间:2015/07/22
Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer's Disease 期刊论文
PROTEIN AND PEPTIDE LETTERS, 2014, 卷号: 21, 期号: 10, 页码: 1048-1056
作者:  Wang, Peipei;  Ding, Kan
收藏  |  浏览/下载:31/0  |  提交时间:2019/01/08
Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent beta-secretase (BACE1) Inhibitors 期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 5, 页码: 5706-5722
作者:  Zou, Yiquan;  Li, Li;  Chen, Wuyan;  Chen, Tiantian;  Ma, Lanping
收藏  |  浏览/下载:19/0  |  提交时间:2019/01/08


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