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期刊论文 [46]
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浏览/检索结果:
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Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer
期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:
Wang, Xin
;
Pei, Gang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/04/28
Amyloid Precursor Protein
Beta-secretase
App
Site
Cleavage
Adam10
Bace1
Localization
Dimerization
Endocytosis
Defining the minimum substrate and charge recognition model of gamma-secretase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Melcher, Karsten
;
Xu, H. Eric
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid beta (A beta)
amyloid precursor protein (APP)
C99, gamma-secretase
minimum substrate
Notch protein
recognition model
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma - secretase cleavage sites
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 38, 页码: 15826-15837
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Harikumar, Kaleeckal G.
;
Miller, Laurence J.
;
Melcher, Karsten
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance
期刊论文
Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/05/09
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (lx2343)
Streptozotocin
Amyloid beta
Pi3k
Autophagy
App/ps1 transgenic mice
Cognitive deficit
Bace1
Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid beta production and clearance
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343)
streptozotocin
amyloid beta
BACE1
PI3K
autophagy
APP/PS1 transgenic mice
cognitive deficit
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio
期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:
Xu, Ting-Hai
;
Yan, Yan
;
Kang, Yanyong
;
Jiang, Yi
;
Melcher, Karsten
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Alzheimer's disease
C99
gamma-secretase
familial Alzheimer disease (FAD)-linked mutations
epsilon-cleavage assay
Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 卷号: 112, 期号: 11, 页码: 3344-3349
作者:
Dang, SY
;
Wu, SJ
;
Wang, JW
;
Li, HB
;
Huang, M
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2015/07/22
intramembrane protease
Alzheimer's disease
PSH
gamma-secretase
beta-amyloid peptide
Trafficking regulation of proteins in Alzheimer's disease
期刊论文
http://dx.doi.org/10.1186/1750-1326-9-6, 2014
Jiang, Shangtong
;
Li, Yanfang
;
Zhang, Xian
;
Bu, Guojun
;
Xu, Huaxi
;
Zhang, Yun-wu
;
卜国军
;
许华曦
;
张云武
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/07/22
AMYLOID PRECURSOR PROTEIN
TRANS-GOLGI NETWORK
GAMMA-SECRETASE ACTIVITY
SORTILIN-RELATED RECEPTOR
BETA PEPTIDE GENERATION
NECROSIS-FACTOR-ALPHA
INTRACELLULAR TRAFFICKING
ENDOPLASMIC-RETICULUM
APOLIPOPROTEIN-E
CLEAVING ENZYME
Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer's Disease
期刊论文
PROTEIN AND PEPTIDE LETTERS, 2014, 卷号: 21, 期号: 10, 页码: 1048-1056
作者:
Wang, Peipei
;
Ding, Kan
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid-beta protein
glycosaminoglycans
proteoglycans
tau protein
Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent beta-secretase (BACE1) Inhibitors
期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 5, 页码: 5706-5722
作者:
Zou, Yiquan
;
Li, Li
;
Chen, Wuyan
;
Chen, Tiantian
;
Ma, Lanping
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
virtual screening
docking
structure-based lead design
crystal structure
indole acylguanidine
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