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Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening
期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 9, 页码: 4917-4924
作者:
Tao, Hongru
;
Wang, Jun
;
Lu, Wenchao
;
Zhang, Rukang
;
Xie, Yiqian
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Identification of a cellularly active SIRT6 allosteric activator
期刊论文
NATURE CHEMICAL BIOLOGY, 2018, 卷号: 14, 期号: 12, 页码: 1118-+
作者:
Huang, Zhimin
;
Zhao, Junxing
;
Deng, Wei
;
Chen, Yingyi
;
Shang, Jialin
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2019/01/08
Expression of acetyl-histone H3 and acetyl-histone H4 in dorsal root ganglion and spinal dorsal horn in rat chronic pain models
期刊论文
LIFE SCIENCES, 2018, 卷号: 211, 页码: 182-188
作者:
Liang, Lingli
;
Tao, Yuan-Xiang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/11/19
Dorsal root ganglion
Acetyl-histone H4
Acetyl-histone H3
Complete Freund's adjuvant
Spinal dorsal horn
Spinal nerve ligation
Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc
期刊论文
Redox Biology, 2017, 卷号: 13, 页码: 482-497
作者:
Yang, Shikun
;
Zhao, Li
;
Han, Yachun
;
Liu, Yu
;
Chen, Chao
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/03
DN
diabetic nephropathy
ROS
reactive oxygen species
HG
high-glucose
SIRT1
sirtuin-1
Ac-H3
acetyl-histone H3
STZ
streptozotocin
AMPK
AMP-activated protein kinase
ECM
extracellular matrix
Nox2
NADPH oxidase 2
EMT
tubular epithelial-mesenchymal transition
DAPI
4′,6-diamidino-2-phenylindole 9
DHE
dihydroethidium
NDRD
non-diabetic renal disease
H&E
hematoxylin-eosin
PAS
periodic acid-Schiff
PASM
periodic acid-silver methenamine
IHC
immunohistochemistry
MDA
malondialdehyde
ChIP
chromatin immunoprecipitation
TC
total cholesterol
BUN
blood urea nitrogen
FN
fibronectin
HBA1C
glycosylated hemoglobin
Scr
serum creatinine
TG
triglyceride
Probucol
Renal injury
Diabetic nephropathy
p66Shc
Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer
期刊论文
ACTA PHARMACEUTICA SINICA B, 2016, 卷号: 6, 期号: 1, 页码: 93-99
作者:
Chen, Danqi
;
Shen, Aijun
;
Fang, Guanghua
;
Liu, Hongchun
;
Zhang, Minmin
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Histone deacetylases inhibitor
Anticancer
Tetrahydroisoquinoline
Structure-activity relationship
Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction
期刊论文
JOURNAL OF PHYSICAL CHEMISTRY B, 2014, 卷号: 118, 期号: 8, 页码: 2009-2019
作者:
Zhang, Xinlei
;
Ouyang, Sisheng
;
Kong, Xiangqian
;
Liang, Zhongjie
;
Lu, Junyan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas
期刊论文
DIAGNOSTIC PATHOLOGY, 2012, 卷号: 7
作者:
Xu, Xiaoming
;
Jin, Huiying
;
Liu, Yafang
;
Liu, Li
;
Wu, Qiong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas
期刊论文
DIAGNOSTIC PATHOLOGY, 2012, 卷号: 7
作者:
Xu, Xiaoming
;
Jin, Huiying
;
Liu, Yafang
;
Liu, Li
;
Wu, Qiong
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
组蛋白去乙酰化酶抑制剂SAHA诱导多发性骨髓瘤细胞株U266细胞凋亡及其机制研究
学位论文
2012, 2012
于涛
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2016/02/14
SAHA
U266细胞
增殖抑制
凋亡
乙酰化H3
p21
p38MAPK
SAHA
U266 cells
inhibition on proliferation
apoptosis
acetyl-H3
p21
p38MAPK
Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
期刊论文
SCIENCE, 2009, 卷号: 325, 期号: 5945, 页码: 1254-1257
作者:
Hait, Nitai C.
;
Allegood, Jeremy
;
Maceyka, Michael
;
Strub, Graham M.
;
Harikumar, Kuzhuvelil B.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
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