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科研机构
上海药物研究所 [36]
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期刊论文 [36]
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2021 [1]
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Oncology [4]
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Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K-AKT-mTOR/JNK pathway
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 卷号: 53, 期号: 5, 页码: 575-583
作者:
Hu, Ke
;
Li, Bo
;
Ma, Ruye
;
Yi, Hongfei
;
Xu, Zhijian
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/06/11
caspase
cell proliferation
cell cycle arrest
diffuse large B-cell lymphoma
PI3K-AKT-mTOR/JNK pathway
Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1)
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 195, 页码: 13
作者:
Zhang, Shiyan
;
Huang, Chaoying
;
Lyu, Xilin
;
Wang, Peipei
;
Zang, Yi
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
ASK1
ASK2
Selectivity
Apoptosis
Cell cycle arrest
aberrantmodulationofribosomalproteins6phosphorylationconfersacquiredresistancetomapkpathwayinhibitorsinbrafmutantmelanoma
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 002, 页码: 268
作者:
Mingzhao Gao
;
Hongbin Wang
;
Xiangling Chen
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
BRAF-mutant
melanoma
MAPK
pathway
inhibitors
acquired
resistance
P70S6K
RSK
rpS6
G1/G0
phase
arrest
mTOR
inhibitor
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Li, Xun
;
Qiu, Zidong
;
Jin, Qinghao
;
Chen, Guilin
;
Guo, Mingquan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
colon cancer
Toddalia asiatica Lam.
G2/M arrest
apoptosis
reactive oxygen species
targetingthepi3kaktmtorsignalingpathwaybypterostilbeneattenuatesmantlecelllymphomaprogression
期刊论文
actabiochimicaetbiophysicasinica, 2018, 卷号: 50, 期号: 8, 页码: 782
作者:
Yu Dandan
;
Zhang Yong
;
Chen Gege
;
Xie Yongsheng
;
Xu Zhijian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
PROTEIN-KINASE PATHWAY
CANCER IN-VITRO
TRANSDUCTION PATHWAYS
CYCLE ARREST
APOPTOSIS
ACTIVATION
PATHOGENESIS
INHIBITION
ANTICANCER
EXPRESSION
mantle cell lymphoma
pterostilbene
antiproliferative activity
PI3K/Akt/mTOR pathway
synergistic cytotoxicity
Marine-derived chromopeptide A, a novel class I HDAC inhibitor, suppresses human prostate cancer cell proliferation and migration
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 4, 页码: 551-560
作者:
Sun, Jing-ya
;
Wang, Ji-dong
;
Wang, Xin
;
Liu, Hong-chun
;
Zhang, Min-min
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
HDAC
chromopeptide A
FK228
human prostate cancer
cell cycle arrest
apoptosis
cancer cell migration
PC3 xenograft model
1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G(2)/M phase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 4, 页码: 561-570
作者:
Peng, Chun
;
Qi, Xin-ming
;
Miao, Ling-ling
;
Ren, Jin
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
1,2:5,6-dianhydrogalactitol
human glioblastoma
cell cycle arrest
p53-p21 cascade
CDC25C-CDK1 cascade
radiosensitivity
xenografted tumors
White matter injury after cardiopulmonary bypass in a brain slice model of neonatal rats with perfusion
期刊论文
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 卷号: 24, 期号: 4, 页码: 295-300
作者:
Huang Junrong
;
Zhu Zhongqun
;
Liu Gang
;
Chen Huiwen
;
Feng Linyin
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Congenital heart disease
cardiopulmonary bypass
deep hypothermic cardiac arrest
white matter
preoligodendrocytes
marinederivedchromopeptideaanovelclassihdacinhibitorsuppresseshumanprostatecancercellproliferationandmigration
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 4, 页码: 551
作者:
Sun Jingya
;
Wang Jidong
;
Wang Xin
;
Liu Hongchun
;
Zhang Minmin
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
HISTONE DEACETYLASE INHIBITORS
ANDROGEN DEPRIVATION THERAPY
ROMIDEPSIN
VORINOSTAT
EXPRESSION
RESISTANCE
TRIAL
DEPSIPEPTIDE
MITOXANTRONE
ABIRATERONE
HDAC
chromopeptide A
FK228
human prostate cancer
cell cycle arrest
apoptosis
cancer cell migration
PC3 xenograft model
1256dianhydrogalactitolinhibitshumangliomacellgrowthinvivoandinvitrobyarrestingthecellcycleatg2mphase
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 4, 页码: 561
作者:
Peng Chun
;
Ql Xinming
;
Miao Lingling
;
Ren Jin
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
NEWLY-DIAGNOSED GLIOBLASTOMA
DNA-DAMAGE
RANDOMIZED-TRIAL
DIANHYDROGALACTITOL
TEMOZOLOMIDE
P53
CANCER
TUMORS
BEVACIZUMAB
COMBINATION
1,2:5,6-dianhydrogalactitol
human glioblastoma
cell cycle arrest
p53-p21 cascade
CDC25C-CDK1 cascade
radiosensitivity
xenografted tumors
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