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科研机构
上海药物研究所 [42]
内容类型
期刊论文 [42]
发表日期
2021 [5]
2020 [4]
2019 [3]
2018 [11]
2017 [6]
2016 [2]
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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Wang, Lin
;
Wu, Yan
;
Yao, Sheng
;
Ge, Huan
;
Zhu, Ya
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  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
SARS-CoV-2
natural products
virtual screening
spike protein
protein-protein interaction modulators
Neolinulicin A and B from Inula japonica and their anti-inflammatory activities
期刊论文
FITOTERAPIA, 2021, 卷号: 152, 页码: 6
作者:
Wu, Rui-fang
;
Zhou, Bing-duo
;
Wang, Wen-qiong
;
Chen, Tong
;
Xu, Ting-ting
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  |  
浏览/下载:17/0
  |  
提交时间:2021/08/17
Inula japonica
Sesquiterpenes
Anti-inflammation
Anti-inflammatory sesquiterpene dimers and diterpenes from the aerial part of Inula japonica
期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 页码: 8
作者:
Wu, Rui-Fang
;
Wang, Wen-Qiong
;
Zhou, Bing-Duo
;
Wang, Yi
;
Li, Ya-Ding
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  |  
浏览/下载:37/0
  |  
提交时间:2021/08/17
Anti-inflammation
composite
ent-kaurane diterpenes
Inula japonica
sesquiterpene dimers
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
收藏
  |  
浏览/下载:114/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
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  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Teratopyrones A-C, Dimeric Naphtho-gamma-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 21, 页码: 10
作者:
Xu, Ya-Ming
;
Arnold, A. Elizabeth
;
U'Ren, Jana M.
;
Xuan, Li-Jiang
;
Wang, Wen-Qiong
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  |  
浏览/下载:19/0
  |  
提交时间:2020/12/24
endophytic fungus
Teratosphaeria
teratopyrones
naphtho-γ
-pyrones
nigerasperone A
Three new dibenzofurans from Cydonia oblonga Mill
期刊论文
NATURAL PRODUCT RESEARCH, 2020, 卷号: 34, 期号: 8, 页码: 1146-1151
作者:
Wei, Jiao-Jiao
;
Wang, Wen-Qiong
;
Song, Wei-Bin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
Cydonia oblonga Mill
dibenzofurans
Rosaceae
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 327-335
作者:
Li, Hui-hui
;
Li, Jun
;
Zhang, Xian-jing
;
Li, Jiao-meng
;
Xi, Cong
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
23,24-dihydrocucurbitacin B
lipid-lowering agent
LDLR
PCSK9
HNF1 alpha
SREBP2
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2020/07/01
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