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科研机构
上海药物研究所 [63]
内容类型
期刊论文 [58]
专利 [3]
会议论文 [2]
发表日期
2021 [3]
2020 [4]
2019 [2]
2018 [6]
2017 [6]
2016 [6]
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Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 8
作者:
Song, Zilan
;
Liu, Yuting
;
Xie, Chenghu
;
Tong, Xiankun
;
Wang, Xue
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浏览/下载:74/0
  |  
提交时间:2021/11/04
Choroquine
Aminochloroquine
Antivirus
Anti-inflammatory
Cytokines
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
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  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
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  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 页码: 6
作者:
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浏览/下载:19/0
  |  
提交时间:2020/12/21
acylation
click chemistry
peptides
rearrangements
silver
Medulloblastoma: Molecular understanding, treatment evolution, and new developments
期刊论文
PHARMACOLOGY & THERAPEUTICS, 2020, 卷号: 210, 页码: 13
作者:
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  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Medulloblastoma
Pediatric brain tumor
Oncogenic driver gene
Hedgehog pathway inhibitor
Smoothened receptor antagonist
Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone
期刊论文
ISCIENCE, 2020, 卷号: 23, 期号: 2, 页码: 46
作者:
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  |  
浏览/下载:145/0
  |  
提交时间:2020/07/01
Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer
期刊论文
CANCER LETTERS, 2020, 卷号: 475, 页码: 22-33
作者:
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  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
Artemisinin
NSCLC
ASNS
ER stress
Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 179, 页码: 38-55
作者:
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浏览/下载:11/0
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提交时间:2020/07/01
Indoleamine 2,3-dioxygenase
Immunotherapy
Oxadiazole
PD-1
Life span
Design and synthesis of novel dual-cyclic RGD peptides for alpha(v)beta(3) integrin targeting
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 7, 页码: 896-900
作者:
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浏览/下载:17/0
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提交时间:2020/07/01
alpha(v)beta(3) integrin
RGD cyclic peptide
Tumor-targeting
Cyclo(RGDfK)
Adhesion inhibition
Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 159, 页码: 149-165
作者:
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浏览/下载:37/0
  |  
提交时间:2019/01/08
Apoptosis
Artemisinin
Bcl-2
Venetoclax
Selectivity
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