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科研机构
上海药物研究所 [25]
内容类型
期刊论文 [25]
发表日期
2021 [25]
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发表日期:2021
专题:上海药物研究所
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Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/18
Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study
期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 11, 页码: 16
作者:
Gao, Meina
;
Li, Hui
;
Ye, Chenghao
;
Chen, Kaixian
;
Jiang, Hualiang
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2022/01/04
DC-SIGN
glycan epitopes
carbohydrate recognition mechanism
natural glycoside antagonists
molecular dynamics simulations
COVID-19
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Strategy of De Novo Design toward First-In-Class Imaging Agents for Simultaneously Differentiating Glioma Boundary and Grades
期刊论文
ACS SENSORS, 2021, 卷号: 6, 期号: 9, 页码: 3330-3339
作者:
Yan, Feng
;
Zhuang, Jianfeng
;
Yu, Qian
;
Dou, Zhangqi
;
Jiang, Xuefeng
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/11/04
fluorescent probe
bioinformatics analysis
PDGFR beta
glioma imaging
glioma grading
Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2021, 卷号: 12, 页码: 14
作者:
Yang, Xinyu
;
Zhang, Xianfeng
;
Yang, Wei
;
Yu, Hang
;
He, Qianyan
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
gut microbiota
adipose tissue dysfunction
molecular endocrinology
cardiovascular disease(s)
gut dysbiosis
Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer
期刊论文
ADVANCED MATERIALS, 2021, 页码: 12
作者:
Zhou, Fengqi
;
Gao, Jing
;
Tang, Yang
;
Zou, Zhifeng
;
Jiao, Shi
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
antigen presentation
autophagy inhibition
immune resistance
immunotherapy
prodrug nanovesicles
Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2111-2120
作者:
Chen, Jian-Jun
;
Bai, Wei
;
Lu, Yu-Bo
;
Feng, Zi-Yun
;
Gao, Kun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/11/04
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:241/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Structurally diverse diterpenoid alkaloids from the lateral roots of Aconitum carmichaelii Debx. and their anti-tumor activities based on in vitro systematic evaluation and network pharmacology analysis
期刊论文
RSC ADVANCES, 2021, 卷号: 11, 期号: 43, 页码: 26594-26606
作者:
Yu, Yang
;
Wu, Shifei
;
Zhang, Jianqing
;
Li, Jiayuan
;
Yao, Changliang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/11/04
Competitive CatSper Activators of Progesterone from Rhynchosia volubilis
期刊论文
PLANTA MEDICA, 2021, 页码: 10
作者:
Xiang, Jin
;
Kang, Hang
;
Li, Hong-Gang
;
Shi, Yu-Long
;
Zhang, Ya-Li
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/11/04
Leguminosae
Rhynchosia volubilis
CatSper
prenylated isoflavonoids
rhynchones A - E
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