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科研机构
上海药物研究所 [22]
内容类型
期刊论文 [22]
发表日期
2020 [22]
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共22条,第1-10条
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发表日期:2020
专题:上海药物研究所
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DCZ3301, an aryl-guanidino agent, inhibits ocular neovascularization via PI3K/AKT and ERK1/2 signaling pathways
期刊论文
EXPERIMENTAL EYE RESEARCH, 2020, 卷号: 201, 页码: 8
作者:
Xu, Kai
;
Li, Bo
;
Zhang, Shujie
;
Hu, Fangyuan
;
Xu, Zhijian
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
DCZ3301
Apoptosis
PI3K/AKT pathway
ERK1/2 pathway
Choroid microvascular sprouting
Corneal neovascularization
Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses Kras-mutated non-small cell lung cancer
期刊论文
MOLECULAR CANCER RESEARCH, 2020, 卷号: 18, 期号: 10, 页码: 44-45
作者:
Wang, Yu-xiang
;
Li, Xian
;
Liu, Xue-ling
;
Wang, Bo-bo
;
Chen, Yi
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020, 页码: 4
作者:
Yu, Bo
;
Li, Chenze
;
Chen, Peng
;
Li, Jia
;
Jiang, Hualiang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/12/24
Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19 (vol 84, pg 913, 2020)
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020, 页码: 2
作者:
Yu, Bo
;
Li, Chenze
;
Chen, Peng
;
Zhou, Ning
;
Wang, Luyun
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/12/24
A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe
期刊论文
Journal of Experimental & Clinical Cancer Research, 2020, 卷号: 39, 期号: 1
作者:
Hu,Liangning
;
Li,Bo
;
Chen,Gege
;
Song,Dongliang
;
Xu,Zhijian
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Multiple myeloma
Drug-resistance
DNA damage response
Cell cycle
A novel phosphoramide compound, DCZ0847, displays in vitro and in vivo anti-myeloma activity, alone or in combination with bortezomib
期刊论文
CANCER LETTERS, 2020, 卷号: 478, 页码: 45-55
作者:
Chen, Gege
;
Hu, Ke
;
Sun, Haiguo
;
Zhou, Jinfeng
;
Song, Dongliang
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2020/07/01
Multiple myeloma
Bone marrow microenvironment
DNA damage
JAK2/STAT3 pathway
Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020, 页码: 7
作者:
Yu Bo
;
Li Chenze
;
Chen Peng
;
Zhou Ning
;
Wang Luyun
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion
期刊论文
ADVANCED SCIENCE, 2020, 页码: 13
作者:
Sun, Zhongya
;
Zhang, Hao
;
Zhang, Yuanyuan
;
Liao, Liping
;
Zhou, Wen
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2020/07/01
anti-metastasis activities
crystal structures
inhibitors
novel pockets
rho family proteins
Qualitative and quantitative determination of anaprazole and its major metabolites in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 183, 页码: 10
作者:
Tang, Chongzhuang
;
Li, Liang
;
Ma, Xifeng
;
Wang, Jin
;
Chen, Bo
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2020/07/01
Metabolite identification
LC-MS/MS
UPLC-UV/Q-TOF
Anaprazole
Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4388-4407
作者:
Li, Zhiqiang
;
Li, Xinzhi
;
Su, Ming-Bo
;
Gao, Li-Xin
;
Zhou, Yu-Bo
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
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