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科研机构
山东大学 [10]
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期刊论文 [10]
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2019 [2]
2018 [2]
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2013 [2]
2011 [1]
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Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 17, 期号: 4, 页码: 3719-3726
作者:
Yuan, Ting
;
Zhang, Feng
;
Zhou, Xiangxiang
;
Li, Ying
;
Zhang, Ya
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/11
diffuse large B-cell lymphoma
proteasome inhibitor
B-cell
lymphoma-2-associated athanogene3
PI3K
RAC-alpha serine
threonine-protein kinase pathway
proliferation
Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 卷号: 20, 期号: 17
作者:
Aasen, Synnove Nymark
;
Parajuli, Himalaya
;
Tuyen Hoang
;
Feng, Zichao
;
Stokke, Krister
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
melanoma
brain metastasis
BRAF
MAPK
PI3K
combined treatment
apoptosis
Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors
期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 151, 页码: 9-17
作者:
Ma C.-C.
;
Zhang C.-M.
;
Tang L.-Q.
;
Liu Z.-P.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
B-Cell inhibition
PI3K isoform selectivity
PI3Kδ inhibitor
PI3Kδ/γ inhibitors
Quinazolinones
Discovery of novel quinazolinone derivatives as high potent and selective PI3K delta and PI3K delta/gamma inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 9-17
作者:
Ma, Chen-Chen
;
Zhang, Cheng-Mei
;
Tang, Long-Qian
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/11
PI3K delta inhibitor
PI3K delta/gamma inhibitors
PI3K isoform
selectivity
B-Cell inhibition
Quinazolinones
Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 4, 页码: 7181-7200
作者:
Liu, Yu
;
Wan, Wen-zhu
;
Li, Yan
;
Zhou, Guan-lian
;
Liu, Xin-guang
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
phosphatidylinostitol-3-kinase
PI3K
inhibitor
mTOR pathway
anticancer
Design and Synthesis of Coumarin Derivatives as Novel PI3K Inhibitors
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 3, 页码: 395-403
作者:
Ma, Chen-Chen
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/12
Anticancer agents
apoptosis
coumarins
Friedel-Crafts alkylation
inhibitors
Pechman reaction
PI3K
PI3K/Akt signal pathway
New development of inhibitors targeting the PI3K/AKT/mTOR pathway in personalized treatment of non-small-cell lung cancer
期刊论文
Anti-cancer drugs, 2015, 卷号: 26, 期号: 1, 页码: 1-14
作者:
Sun, Zhenguo
;
Wang, Zhou
;
Liu, Xiangyan
;
Wang, Dong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
drug resistance
non-small-cell lung cancer
personalized therapy
PI3K/AKT/mTOR pathway
Recent Developments of Small Molecule PI3K/mTOR Dual Inhibitors
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2013, 卷号: 13, 期号: 14, 页码: 2047-2059
作者:
Liu, Yan-Na
;
Wan, Ren-Zhong
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
Anticancer
anticancer agents
cancer
dual PI3K/mTOR kinase inhibitors
kinase inhibitors
PI3K
PI3K alpha
PI3K/Akt/mTOR
PI3K signaling
pathway
mTOR
structure-activity relationships
SARs
Preparation of S14161 and its analogues and the discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a more potent antitumor agent in vitro
期刊论文
Bioorganic and Medicinal Chemistry Letters, 2013, 卷号: 23, 期号: 11, 页码: 3314-3319
作者:
Yin,S.-Q.
;
Shi,M.
;
Kong,T.-T.
;
Zhang,C.-M.
;
Han,K.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/23
3-kinase pathway (PI3K)
3-Nitro-2H-chromene
Akt phosphorylation
Antiproliferative
Antitumor
Apoptosis
inhibitors
Oxa-Michael-Henry reaction
Phosphoinositide
Developments in Selective Small Molecule ATP-Competitive Inhibitors Targeting the Serine/Threonine Kinase Akt/PKB
期刊论文
Mini reviews in medicinal chemistry, 2011, 卷号: 11, 期号: 13, 页码: 1093-1107
作者:
P. Wang
;
L. Zhang
;
Q. Hao
;
G. Zhao
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/23
Akt
ATP-competitive inhibitors
PI3K/Akt signaling pathway
selective.
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