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科研机构
中国科学院大学 [8]
内容类型
期刊论文 [8]
发表日期
2016 [2]
2010 [1]
2009 [1]
2008 [3]
2006 [1]
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专题:中国科学院大学
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Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance
期刊论文
Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/05/09
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (lx2343)
Streptozotocin
Amyloid beta
Pi3k
Autophagy
App/ps1 transgenic mice
Cognitive deficit
Bace1
Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of alzheimer's disease
期刊论文
Metallomics, 2016, 卷号: 8, 期号: 8, 页码: 782-789
作者:
Zhang, Zhong-Hao
;
Chen, Chen
;
Wu, Qiu-Yan
;
Zheng, Rui
;
Liu, Qiong
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/05/09
Potential protection of curcumin against intracellular amyloid beta-induced toxicity in cultured rat prefrontal cortical neurons
期刊论文
Neuroscience letters, 2010, 卷号: 480, 期号: 1, 页码: 21-24
作者:
Qin, Xiao-Yan
;
Cheng, Yong
;
Yu, Long-Chuan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/05/10
Curcumin
Intracellular a beta
Prefrontal cortical neurons
Caspase-3
Akt
Neuronal protective effect
Amyloid deposition and inflammation in appswe/ps1de9 mouse model of alzheimer's disease
期刊论文
Current alzheimer research, 2009, 卷号: 6, 期号: 6, 页码: 531-540
作者:
Ruan, Lingfei
;
Kang, Zhoujun
;
Pei, Gang
;
Le, Yingying
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/05/10
Alzheimer's disease
Appswe/ps1de9
Transgenic mouse
Amyloid deposition
Inflammation
Microglia
Astrocyte
Neuron
The binding of thioflavin t and its neutral analog bta-1 to protofibrils of the alzheimer's disease a beta(16-22) peptide probed by molecular dynamics simulations
期刊论文
Journal of molecular biology, 2008, 卷号: 384, 期号: 3, 页码: 718-729
作者:
Wu, Chun
;
Wang, Zhixiang
;
Lei, Hongxing
;
Duan, Yong
;
Bowers, Michael T.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/05/10
Amyloid fibrils
Alzheimer's disease a beta(16-22) peptide
Aggregation
Thioflavin t
Molecular dynamics simulations
Biological characters of [f-18]o-fet-pib in a rat model of alzheimer's disease using micro-pet imaging
期刊论文
Acta pharmacologica sinica, 2008, 卷号: 29, 期号: 5, 页码: 548-554
作者:
Zheng, Ming-qiang
;
Yin, Duan-zhi
;
Zhang, Lan
;
Lei, Bei
;
Cheng, Deng-feng
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/05/10
Micro-positron emission tomography
[f-18]o-fet-pib
Alzheimer's disease
Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for beta-amyloid plaques in alzheimer's disease
期刊论文
Journal of fluorine chemistry, 2008, 卷号: 129, 期号: 3, 页码: 210-216
作者:
Zheng, Ming-Qiang
;
Yin, Duan-Zhi
;
Qiao, Jin-Ping
;
Zhang, Lan
;
Wang, Yong-Xian
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/05/10
Alzheimer's disease
F-n-me
F-n,n-me
[(18)f]o-fet-pib
Pet
Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein swedish mutation overexpressing sh-sy5y cells
期刊论文
Neuroscience, 2006, 卷号: 143, 期号: 1, 页码: 63-72
作者:
Zhang, J.
;
Mori, A.
;
Chen, Q.
;
Zhao, B.
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/05/10
Alzheimer's disease
Copper
Beta-amyloid
Papaya
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