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科研机构
上海药物研究所 [1047]
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期刊论文 [1037]
会议论文 [7]
学位论文 [3]
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2021 [59]
2020 [47]
2019 [65]
2018 [91]
2017 [78]
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Pharmacolo... [9]
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Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 卷号: 1867, 期号: 2, 页码: 13
作者:
Lu, Dasheng
;
Liu, Yameng
;
Luo, Yuhong
;
Zhao, Jie
;
Feng, Chao
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2022/01/18
Fatty acid oxidation
Acylcarnitines
FXR
FGF15/19
PGC1 alpha
Transcriptomics
Metabolomics
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF beta signaling
期刊论文
ONCOGENE, 2021, 页码: 10
作者:
Kong, Ya
;
Zhang, Yutian
;
Wang, Hanlin
;
Kan, Weijuan
;
Guo, Haoran
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2022/01/04
SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade
期刊论文
EMBO JOURNAL, 2021, 页码: 16
作者:
Wang, Xu
;
Ni, Jiahui
;
You, Yan
;
Feng, Guize
;
Zhang, Sulin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/12/16
E-cadherin
IBD
intestinal barrier function
LPS release
SNX10
Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells
期刊论文
LIFE SCIENCES, 2021, 卷号: 284, 页码: 7
作者:
Wang, Yuqiu
;
Duan, Tianbi
;
Hong, Minhua
;
Zhou, Yanting
;
Huang, Hui
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Silk fibroin
Quantitative proteomics
Melanin
Microphthalmia-associated transcription factor
Tyrosinase
Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A-Induced Liver Injury Mice
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 379, 期号: 2, 页码: 125-133
作者:
Han, Li
;
Ma, Chenhui
;
Peng, Huige
;
Wu, Zhitao
;
Xu, Huiming
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/01/04
Genetically-engineered "all-in-one" vaccine platform for cancer immunotherapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 11, 页码: 3622-3635
作者:
Wu, Aihua
;
Chen, Yingzhi
;
Wang, Hairui
;
Chang, Ya
;
Zhang, Meng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/18
Trichosanthin
Legumain
TRP2
Transcutaneous immunization
Adjuvant
Cancer vaccine
Protein engineering
Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy
期刊论文
STEM CELL RESEARCH & THERAPY, 2021, 卷号: 12, 期号: 1, 页码: 12
作者:
Ma, Chen
;
Zhang, Ludi
;
He, Ting
;
Cao, Huiying
;
Ren, Xiongzhao
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/12/01
Raman spectroscopy
Cell therapy
Identification
Proliferating human hepatocytes
Dedifferentiation
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