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科研机构
上海药物研究所 [32]
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期刊论文 [32]
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2021 [1]
2020 [3]
2019 [1]
2018 [5]
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Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 17
作者:
Lin, Lin
;
Lin, Guangyao
;
Zhou, Qingtong
;
Bathgate, Ross A. D.
;
Gong, Grace Qun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Synthesis
Structure-activity relationship
Relaxin family peptide receptor 4
Selective agonist
Molecular docking
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery
期刊论文
BIOMATERIALS, 2020, 卷号: 255, 页码: 12
作者:
Chen, Binfan
;
Gao, Ang
;
Tu, Bin
;
Wang, Yonghui
;
Yu, Xiaolu
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/12/24
Tumor-associated macrophage
Glycolysis
mTOR
Angiogenesis
Tumor immune microenvironment
Liposome
Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 13
作者:
Yuliantie, Elita
;
Darbalaei, Sanaz
;
Dai, Antao
;
Zhao, Peishen
;
Yang, Dehua
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/24
G protein-coupled receptor
Glucose-dependent insulinotropic peptide receptor
Glucagon-like peptide-1 receptor
Biased agonist
GPCR signaling
Discovery of betulinaldehyde as a natural ROR gamma t agonist
期刊论文
FITOTERAPIA, 2019, 卷号: 137, 页码: 8
作者:
Yang, Feng
;
Zhang, Ruihan
;
Ni, Dongxuan
;
Luo, Xiaomin
;
Chen, Shijie
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
ROR gamma t
Receptor agonist
Triterpenoids
Alpha screen
Molecular docking
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophagemediated immunotherapy
期刊论文
CHEMICAL SCIENCE, 2018, 卷号: 9, 期号: 10, 页码: 2674-2689
作者:
Zhao, Pengfei
;
Wang, Yonghui
;
Kang, Xuejia
;
Wu, Aihua
;
Yin, Weimin
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  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites
期刊论文
BIOMATERIALS, 2018, 卷号: 158, 页码: 56-73
作者:
Xu, Fan
;
Zhong, Huihai
;
Chang, Ya
;
Li, Dongdong
;
Jin, Hongyue
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
TRAIL
Gene delivery
Monensin
Poly-gamma-glutamic acid
Death receptor
Drug resistance
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Structure of the glucagon receptor in complex with a glucagon analogue
期刊论文
NATURE, 2018, 卷号: 553, 期号: 7686, 页码: 106-+
作者:
Zhang, Haonan
;
Qiao, Anna
;
Yang, Linlin
;
Van Eps, Ned
;
Frederiksen, Klaus S.
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  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
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