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科研机构
上海药物研究所 [21]
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期刊论文 [20]
学位论文 [1]
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2021 [1]
2017 [1]
2014 [1]
2013 [2]
2012 [1]
2011 [1]
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Chemistry [3]
Pharmacolo... [2]
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A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
Synthesis and antitumor activity of a series of lactone-opened camptothecin derivatives
期刊论文
Journal of Asian natural products research, 2017, 页码: 1-11
作者:
Zheng, Chao
;
Li, Ming-Zong
;
You, Tian-Pa
;
Tang, Wei-Ping
;
Lou, Li-Guang
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Development and validation of a sensitive LC-MS/MS method for simultaneous quantification of sinotecan and its active metabolite in human blood
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2014, 卷号: 951, 页码: 62-68
作者:
Yu, Yang
;
Zhan, Yan
;
Chen, Xiaoyan
;
Zhang, Yifan
;
Zhong, Dafang
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Sinotecan
7-Hydroxyethyl-camptothecin
LC-MS/MS
Pharmacokinetics
Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 11, 页码: 1437-1448
作者:
Hu, Zhe-yi
;
Li, Xiu-xue
;
Du, Fei-fei
;
Yang, Jun-ling
;
Niu, Wei
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
pharmacokinetics
distribution
metabolism
excretion
L-P
L-2-Z
carboxylesterase
species difference
prodrug
RP-HPLC determination of irinotecan hydrochloride(CPT-11) and its related substances
期刊论文
Chinese Journal of Pharmaceutical Analysis, 2013, 卷号: 33, 期号: 3, 页码: 439-442
作者:
Qiao Shanbao
;
Ji Min
;
Xiang Lili
;
Chen Dongying
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
HPLC
ion - pair
irinotecan hydrochloride (CPT - 11)
impurity analysis
forced degradation
quality control
camptothecin derivatives
Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2012, 卷号: 22, 期号: 8, 页码: 1586-1597
作者:
Chen, Yu
;
Gao, Yu
;
Chen, Hangrong
;
Zeng, Deping
;
Li, Yaping
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  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
mesoporous silica
selective etching
emulsions
liposomes
hydrophobic agents
Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2011, 卷号: 1218, 期号: 38, 页码: 6646-6653
作者:
Hu, Zheyi
;
Sun, Yan
;
Du, Feifei
;
Niu, Wei
;
Xu, Fang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Simmitecan
Chimmitecan
Irinotecan
Camptothecin
Prodrug
Carboxylesterase
Bis(4-nitrophenyl)phosphate
Pulse gradient chromatography
Matrix effects
Effect of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) micelles on pharmacokinetics and intestinal toxicity of irinotecan hydrochloride: potential involvement of breast cancer resistance protein (ABCG2)
期刊论文
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2010, 卷号: 62, 期号: 8, 页码: 973-984
作者:
Guo, Shiyan
;
Zhang, Xinxin
;
Gan, Li
;
Zhu, Chunliu
;
Gan, Yong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
biliary excretion
breast cancer resistance protein (BCRP)
intestinal toxicity
irinotecan hydrochloride (CPT-11)
poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) micelles
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