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上海药物研究所 [14]
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期刊论文 [12]
会议论文 [1]
学位论文 [1]
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2018 [1]
2017 [1]
2010 [2]
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Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2 ',3 ': 4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5 '-monophosphate-activated protein kinase (AMPK)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2017-2027
作者:
Gu, Zhanni
;
Wu, Lingyan
;
Duan, Yanan
;
Wang, Jiang
;
Zhou, Shengbin
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Adenosine 5 '-monophosphate-activated protein kinase
AMPK activators
Berberine
Tetrahydroberberine
T2DM
Design, synthesis and. biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5 '-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 448-464
作者:
Zhou, Shengbin
;
Duan, Yanan
;
Wang, Jiang
;
Zhang, Jin
;
Sun, Haifeng
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Tetrahydroberberine
4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines
Mitochondrial respiration
AMPK indirect activators
db/db mice
Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta
期刊论文
NEUROPHARMACOLOGY, 2010, 卷号: 59, 期号: 7-8, 页码: 567-572
作者:
Wu, Chen
;
Yang, Kechun
;
Liu, Qiang
;
Wakui, Matoko
;
Jin, Guo-Zhang
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Tetrahydroberberine
Dopaminergic neurons
Substantia nigra compacta
ATP-sensitive K+ channel
Rotenone
Parch-clamp
NMR Characterization and Structural Elucidation of Fluorine Derivative of Tetrahydroberberine
期刊论文
Chinese Journal of Magnetic Resonance, 2009, 卷号: 26, 期号: 1, 页码: 111-119
作者:
ZHANG Pei-xuan
;
LI Jian-feng
;
WEI Ya-bing
;
SHEN Jing-shan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
nuclear magnetic resonance
structure elucidation
mass spectrometry
fluoro tetrahydroberberine
Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus
期刊论文
BRAIN RESEARCH, 1997, 卷号: 775, 期号: 1-2, 页码: 214-218
作者:
Wu, J
;
Jin, GZ
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
tetrahydroberberine
K+ current
K+ channel
hippocampus
dissociated neuron
patch clamp
Tetrahydroberberine inhibits acetylcholine-induced K+ current in acutely dissociated rat hippocampal CA1 pyramidal neurons
期刊论文
NEUROSCIENCE LETTERS, 1997, 卷号: 222, 期号: 2, 页码: 115-118
作者:
Wu, J
;
Jin, GZ
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
tetrahydroberberine
acetylcholine
K+ current
rat hippocampus
dissociated neurons
patch-clamp
Tetrahydroprotoberberine analogs antagonize alpha(1)-adrenoceptors and inhibit mobilization of intracellular calcium
期刊论文
DRUG DEVELOPMENT RESEARCH, 1996, 卷号: 39, 期号: 2, 页码: 191-196
作者:
Han, CD
;
Lu, ZZ
;
Wei, X
;
Jin, GZ
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
herbs
adrenergic alpha-antagonists
calcium
blood vessel
Tetrahydroberberine suppresses dopamine-induced potassium current in acutely dissociated CA1 pyramidal neurons from rat hippocampus
期刊论文
NEUROSCIENCE LETTERS, 1996, 卷号: 207, 期号: 3, 页码: 155-158
作者:
Wu, J
;
Jin, GZ
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
tetrahydroberberine
dopamine
K+ current
rat hippocampus
dissociated neurons
patch-clamp
On the central inhibition action of tetrahydroberberine without relevance to GABA receptors
会议论文
作者:
Wang, X L
;
Jin, G Z
;
Zhou, T C
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
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