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科研机构
上海药物研究所 [93]
内容类型
期刊论文 [89]
会议论文 [2]
学位论文 [2]
发表日期
2021 [8]
2020 [4]
2019 [7]
2018 [11]
2017 [5]
2016 [8]
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Pharmacolo... [2]
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Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125
作者:
Zhang, Huimin
;
He, Jixiao
;
Hu, Guang
;
Zhu, Fei
;
Jiang, Hao
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  |  
浏览/下载:36/0
  |  
提交时间:2022/01/04
Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3204-3213
作者:
Zheng Zhang
;
Dai Chengqiu
;
Wu Honghong
;
Li Jingya
;
Nan Fajun
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  |  
浏览/下载:20/0
  |  
提交时间:2021/11/04
death associated apoptotic protein kinase 2
diabetes
alkylphenols
inhibitors
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 17
作者:
Lin, Lin
;
Lin, Guangyao
;
Zhou, Qingtong
;
Bathgate, Ross A. D.
;
Gong, Grace Qun
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  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Synthesis
Structure-activity relationship
Relaxin family peptide receptor 4
Selective agonist
Molecular docking
Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 213, 页码: 17
作者:
Xiao, Xuanzheng
;
Lai, Mengzhen
;
Song, Zilan
;
Geng, Meiyu
;
Ding, Jian
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  |  
浏览/下载:48/0
  |  
提交时间:2021/05/24
KRAS
Covalent inhibitor
Pyridopyrimidinone
Antiproliferative effect
Scaffold hopping
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 9
作者:
Gu, Dongyan
;
Cheng, Gang
;
Zhang, Mengmeng
;
Zhou, Yu-Bo
;
Li, Jia
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  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
PI3K alpha inhibitors
Virtual screening
2-(5-(quinolin-6-yl)-1,3,4 oxadiazol-2-yl)acetamide
Molecular dynamics
Synthesis of new derivatives of alepterolic acid via click chemistry
期刊论文
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2021, 卷号: 86, 期号: 10, 页码: 917-925
作者:
Jin, X. I. N.
;
Cao, Jianguo
;
Zhao, Qingjie
;
Wang, Qi
;
Guo, Hongmei
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  |  
浏览/下载:7/0
  |  
提交时间:2021/11/04
diterpenoid
1,2,3-triazole
structural modification
Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:
Zhang, Bin
;
Liao, Liping
;
Wu, Fan
;
Zhang, Fengcai
;
Sun, Zhongya
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
SMYD2 inhibitors
Thermal shift assay
Structure-activity relationships
The impact of structural modification of sulfated polysaccharides on bone morphogenic protein 2 and inhibition of endothelial cell angiogenesis
期刊论文
CARBOHYDRATE RESEARCH, 2020, 卷号: 496, 页码: 10
作者:
Wang, Ying
;
Xiao, Fei
;
Jin, Can
;
Wang, Wucheng
;
Chen, Xia
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/21
Sulfated polysaccharides
Bone morphogenic protein 2
Structure and activity relationship
Angiogenesis
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