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浏览/检索结果: 共6条，第1-6条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity 期刊论文 ISCIENCE, 2021, 卷号: 24, 期号: 11, 页码: 22 作者:  Hu, Lin;  Chen, Fuxian;  Wu, Chao;  Wang, Jun;  Chen, Si-si 收藏  |  浏览/下载：38/0  |  提交时间：2022/01/18 Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors 期刊论文 ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 3, 页码: 397-403 作者:  Li, Chunpu;  Hu, Sha-Sha;  Yang, Lisheng;  Wang, Min;  Long, Jian-Dong 收藏  |  浏览/下载：57/0  |  提交时间：2021/05/24 SIRT1  inhibitor  structure-activity relationship  interaction  deacetylase   SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13 作者:  Ren, Yu-ran;  Ye, Yang-liang;  Feng, Ying;  Xu, Ti-fei;  Shen, Yu 收藏  |  浏览/下载：22/0  |  提交时间：2021/05/24 SL010110  gluconeogenesis  primary mouse hepatocytes  PEPCK1  acetylation  degradation   Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5 期刊论文 MOLECULES, 2020, 卷号: 25, 期号: 12, 页码: 18 作者:  Han, Haozhen;  Li, Chunpu;  Li, Man;  Yang, Lisheng;  Zhao, Sen 收藏  |  浏览/下载：36/0  |  提交时间：2020/12/24 sirtuins  inhibitor  structure-activity relationship  deacetylase   Molecular dynamics simulations reveal the mechanism of the interactions between the inhibitors and SIRT2 at atom level 期刊论文 MOLECULAR SIMULATION, 2020, 卷号: 46, 期号: 8, 页码: 638-649 作者:  Wang, Xiaoyu;  Song, Menghua;  Zhao, Shuang;  Li, Huiyu;  Zhao, Qingjie 收藏  |  浏览/下载：35/0  |  提交时间：2020/07/01 SIRT2  inhibitor  molecular dynamics simulation  TCMs  hydrophobic and pi-pi interactions   The mimics of N-epsilon-acyl-lysine derived from cysteine as sirtuin inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 14, 页码: 2375-2378 作者:  Wang, Chun;  Wang, Fang;  Chen, Xiaoxue;  Zou, Yefang;  Zhu, Hong 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 L-Cysteine  The mimics of lysine  Mechanism-based inhibitors  Sirtuin inhibitors  SIRT2 inhibitors