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科研机构
上海药物研究所 [12]
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期刊论文 [12]
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2016 [1]
2014 [1]
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Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 105-110
作者:
Yue, Jin-feng
;
Qiao, Guan-hua
;
Liu, Ni
;
Chen, Xue-qin
;
Nan, Fa-jun
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Development of Mechanostimulated Patch-Clamp System for Cellular Physiological Study
期刊论文
IEEE-ASME TRANSACTIONS ON MECHATRONICS, 2014, 卷号: 19, 期号: 4, 页码: 1138-1147
作者:
Zhang, Changlin
;
Li, Peng
;
Liu, Lianqing
;
Wang, Yuechao
;
Gao, Zhaobing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Atomic force microscope (AFM)
mechanosensitive (MS) ion channel
planar patch clamp
Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta
期刊论文
NEUROPHARMACOLOGY, 2010, 卷号: 59, 期号: 7-8, 页码: 567-572
作者:
Wu, Chen
;
Yang, Kechun
;
Liu, Qiang
;
Wakui, Matoko
;
Jin, Guo-Zhang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Tetrahydroberberine
Dopaminergic neurons
Substantia nigra compacta
ATP-sensitive K+ channel
Rotenone
Parch-clamp
Electrophysiological characterization of a novel Kv channel blocker N,N '-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide found in virtual screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 4, 页码: 405-412
作者:
Gao, Zhao-bing
;
Chen, Xue-qin
;
Jiang, Hua-liang
;
Liu, Hong
;
Hu, Guo-yuan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
blocker
hippocampal neurons
N,N '-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide
patch-clamping recording
virtual screening
voltage-gated K(+)channel
Solution structure of BmKK2, a new potassium channel blocker from the venom of Chinese scorpion Buthus martensi Karsch
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2004, 卷号: 55, 期号: 4, 页码: 835-845
作者:
Zhang, NX
;
Li, MH
;
Chen, X
;
Wang, Y
;
Wu, G
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
BmKK2
Buthus martensi Karsch
scorpion toxin
NMR solution structure
potassium
channel blocker
rSK channel
Kv channel
Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion
期刊论文
JOURNAL OF NEUROPHYSIOLOGY, 2002, 卷号: 87, 期号: 6, 页码: 2676-2683
作者:
Hu, GY
;
Biro, Z
;
Hill, RH
;
Grillner, S
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Modulation of NMDA receptor by huperzine A in rat cerebral cortex
期刊论文
ACTA PHARMACOLOGICA SINICA, 1999, 卷号: 20, 期号: 1, 页码: 31-35
作者:
Wang, XD
;
Zhang, JM
;
Yang, HH
;
Hu, GY
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
huperzine A
cholinesterase inhibitors
N-methyl-D-aspartate receptors
sodium glutamate
dizocilpine maleate
hippocampus
pyramidal cells
cerebral cortex
patch-clamp techniques
radioligand assay
Dual effects of pentobarbital on rat sacral dorsal commissural neurons in vitro
期刊论文
ACTA PHARMACOLOGICA SINICA, 1998, 卷号: 19, 期号: 4, 页码: 327-331
作者:
Pang, ZP
;
Xu, TL
;
Hu, GY
;
Li, JS
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
pentobarbital
GABA
patch-clamp techniques
neurons
spinal cord
Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus
期刊论文
BRAIN RESEARCH, 1997, 卷号: 775, 期号: 1-2, 页码: 214-218
作者:
Wu, J
;
Jin, GZ
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
tetrahydroberberine
K+ current
K+ channel
hippocampus
dissociated neuron
patch clamp
Tetrahydroberberine inhibits acetylcholine-induced K+ current in acutely dissociated rat hippocampal CA1 pyramidal neurons
期刊论文
NEUROSCIENCE LETTERS, 1997, 卷号: 222, 期号: 2, 页码: 115-118
作者:
Wu, J
;
Jin, GZ
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
tetrahydroberberine
acetylcholine
K+ current
rat hippocampus
dissociated neurons
patch-clamp
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