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科研机构
上海药物研究所 [145]
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期刊论文 [124]
会议论文 [20]
学位论文 [1]
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2021 [4]
2020 [2]
2019 [3]
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2017 [5]
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共145条,第1-10条
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
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  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
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  |  
浏览/下载:69/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Liu, Xiao-yun
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Zhang, Yi-fan
;
Zhou, Jia-lan
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2020/07/01
alflutinib
AST5902
metabolism
enzyme induction
drug-drug interaction
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:46/0
  |  
提交时间:2020/07/01
Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1351-1363
作者:
Pintusophon, Salisa
;
Niu, Wei
;
Duan, Xiao-na
;
Olaleye, Olajide E.
;
Huang, Yu-hong
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  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
ginsenoside
cytochrome P450 3A
organic anion-transporting polypeptide 1B3
herbal medicine-drug interactions
XueShuanTong
Panax notoginseng
Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids
期刊论文
ARCHIVES OF TOXICOLOGY, 2019, 卷号: 93, 期号: 8, 页码: 2197-2209
作者:
Yang, Mengbi
;
Ma, Jiang
;
Ruan, Jianqing
;
Ye, Yang
;
Fu, Peter Pi-Cheng
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
Pyrrolizidine alkaloid N-oxides
Pyrrolizidine alkaloids
Pyrrolizidine alkaloid N-oxide toxicity
Biotransformation of pyrrolizidine alkaloid N-oxides
Microbiota biotransformation
Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
期刊论文
DRUG METABOLISM AND DISPOSITION, 2019, 卷号: 47, 期号: 4, 页码: 364-376
作者:
Wang, Fengling
;
Wu, Yifan
;
Zhang, Jiwen
;
Wang, Huihui
;
Xie, Xiaoting
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests
期刊论文
Mutagenesis, 2018
作者:
Liu, Weiying
;
Xi, Jing
;
Cao, Yiyi
;
You, Xinyue
;
Chen, Ruixue
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  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
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