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科研机构
上海药物研究所 [24]
内容类型
期刊论文 [24]
发表日期
2020 [4]
2019 [2]
2018 [1]
2017 [2]
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2011 [1]
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Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Xie, Zhu-qing
;
Tian, Xiao-ting
;
Zheng, Yue-ming
;
Zhan, Li
;
Chen, Xue-qin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
geissoschizine methyl ether
Uncaria rhynchophyll
antiepileptic drug
hippocampal neurons
action potential
nicotinic acetylcholine receptors
voltage-gated ion channels
mouse seizure model
Synthetic antibodies against BRIL as universal fiducial marks for single?particle cryoEM structure determination of membrane proteins
期刊论文
naturecommunications, 2020, 卷号: 11, 期号: 1, 页码: 1
作者:
Somnath Mukherjee
;
Satchal K. Erramilli
;
Mark Ammirati
;
Frances J. D. Alvarez
;
Kimberly F. Fennell
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery
期刊论文
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 卷号: 8, 期号: 2, 页码: 16
作者:
Zheng, Zening
;
Zhang, Jiaxin
;
Jiang, Jizong
;
He, Yang
;
Zhang, Wenyuan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/24
tumor microenvironment
macrophages
brain neoplasms
immunotherapy
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins
期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1
作者:
Mukherjee, Somnath
;
Erramilli, Satchal K
;
Ammirati, Mark
;
Alvarez, Frances J D
;
Fennell, Kimberly F
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2021/12/01
Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1386-1393
作者:
Cui, Xue
;
Guo, Yu-e
;
Fang, Jia-hui
;
Shi, Chang-jie
;
Suo, Na
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2020/07/01
donepezil
aricept
oligodendrocyte
oligodendrocyte progenitor cell
differentiation
myelin sheaths
remyelination
CNS demyelinating disorders
multiple sclerosis
donepeziladrugforalzheimersdiseasepromotesoligodendrocytegenerationandremyelination
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 11, 页码: 1386
作者:
Cui Xue
;
Guo Yue
;
Fang Jiahui
;
Shi Changjie
;
Suo Na
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/07/01
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
NICOTINIC ACETYLCHOLINE-RECEPTORS
CENTRAL-NERVOUS-SYSTEM
THYROID-HORMONE
MYELINATION
INHIBITORS
NEUROPROTECTION
CELL
ACTIVATION
GROWTH
donepezil
aricept
oligodendrocyte
oligodendrocyte progenitor cell
differentiation
myelin sheaths
remyelination
CNS demyelinating disorders
multiple sclerosis
Aminobenzisoxazole compounds as agonists of alpha 7 nicotinic acetylcholine receptors: a patent evaluation (WO 2017027600)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2018, 卷号: 28, 期号: 5, 页码: 429-436
作者:
He, Yang
;
Shen, Jingshan
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Nicotinic receptors
alpha 7 nAchR
cognition
agonists
allosteric modulators
Amyloid beta: structure, biology and structure-based therapeutic development
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235
作者:
Chen, Guo-fang
;
Xu, Ting-hai
;
Yan, Yan
;
Zhou, Yu-ren
;
Jiang, Yi
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205
作者:
Chen Guofang
;
Xu Tinghai
;
Yan Yan
;
Zhou Yuren
;
Jiang Yi
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
BLOOD-BRAIN-BARRIER
INSULIN-DEGRADING ENZYME
SOLID-STATE NMR
NICOTINIC ACETYLCHOLINE-RECEPTORS
METABOTROPIC GLUTAMATE RECEPTORS
ATOMIC-FORCE MICROSCOPY
GAMMA-SECRETASE COMPLEX
SMOOTH-MUSCLE-CELLS
AMELIORATES MEMORY IMPAIRMENT
ENDOTHELIN-CONVERTING ENZYME
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 8, 页码: 895-907
作者:
Wu, Zhong-shan
;
Cheng, Hao
;
Jiang, Yi
;
Melcher, Karsten
;
Xu, H. Eric
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
nAChR
5-HT3R
structure biology
subunit composition
channel activation
channel gating
ion selectivity
neurological disorders
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