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科研机构
上海药物研究所 [15]
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期刊论文 [15]
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2020 [1]
2019 [3]
2016 [1]
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2011 [1]
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Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-alpha and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells
期刊论文
PHYTOMEDICINE, 2020, 卷号: 68, 页码: 12
作者:
Wu, Qing-Chang
;
Tang, Xi-Yang
;
Dai, Zi-Qin
;
Dai, Yi
;
Xiao, Hui-Hui
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Sweroside
Differentiation and mineralization
Membrane estrogen receptor-alpha
GPR30
P38 signaling pathway
MC3T3-E1 cells
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal -actinin-4 expression and stabilizing integrin-cytoskeleton linkage
期刊论文
ARTHRITIS RESEARCH & THERAPY, 2019, 卷号: 21, 页码: 16
作者:
He, Shijun
;
Liu, Xing
;
Lin, Zemin
;
Liu, Yuting
;
Gu, Lei
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
SAHH inhibitor
Lupus nephritis
-Actinin-4
Integrin-linked kinase
Integrin
Focal adhesion
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage
期刊论文
Arthritis Research & Therapy, 2019, 卷号: 21, 期号: 1
作者:
He,Shijun
;
Liu,Xing
;
Lin,Zemin
;
Liu,Yuting
;
Gu,Lei
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2020/07/01
SAHH inhibitor
Lupus nephritis
α-Actinin-4
Integrin-linked kinase
Integrin
Focal adhesion
Elucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 卷号: 113, 期号: 50, 页码: E8051-E8058
作者:
Bai, Fang
;
Morcos, Faruck
;
Cheng, Ryan R.
;
Jiang, Hualiang
;
Onuchic, Jose N.
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  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
protein-protein interface
druggable surface
hot spots
direct coupling analysis
drug design
Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 卷号: 290, 期号: 5, 页码: 3149-3160
作者:
Deng, Si-Si
;
Wu, Le-Yu
;
Wang, Ya-Chao
;
Cao, Peng-Rong
;
Xu, Lei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Microtubule
Microtubule-associated Protein (MAP)
Neurite Outgrowth
Protein Kinase A (PKA)
Tau Protein (Tau)
MARK2
Prediction of Enzyme's Family Based on Protein-Protein Interaction Network
期刊论文
CURRENT BIOINFORMATICS, 2015, 卷号: 10, 期号: 1, 页码: 16-21
作者:
Niu, Bing
;
Lu, Yin
;
Lu, Jing
;
Chen, Fuxue
;
Zhao, Tonghui
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Amino acid frequency
enzyme family classes
jackknife test
PPI network-based method
Predicting network of drug-enzyme interaction based on machine learning method
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2014, 卷号: 1844, 期号: 1, 页码: 214-223
作者:
Niu, Bing
;
Zhang, Yuchao
;
Ding, Juan
;
Lu, Yin
;
Wang, Miao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Drug-enzyme interaction
CfsSubset
Machine learning
Random Forest
Pseudo amino acid composition
Molecular descriptor
TRAPPC4-ERK2 Interaction Activates ERK1/2, Modulates Its Nuclear Localization and Regulates Proliferation and Apoptosis of Colorectal Cancer Cells
期刊论文
PLOS ONE, 2011, 卷号: 6, 期号: 8
作者:
Zhao, Shu-Liang
;
Hong, Jie
;
Xie, Zuo-Quan
;
Tang, Jie-Ting
;
Su, Wen-Yu
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Interaction of Proteins with Metal Ions Studied by NMR Techniques: A Review
期刊论文
Chinese Journal of Magnetic Resonance, 2009, 卷号: 26, 期号: 1, 页码: 136-149
作者:
ZHANG Fang
;
LIN Dong-hai
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
NMR
protein-metal ion interaction
chemical shift mapping
backbone dynamics
paramagnetic effect
3D structure.
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