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科研机构
上海药物研究所 [39]
内容类型
期刊论文 [39]
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2020 [1]
2019 [2]
2017 [2]
2016 [1]
2014 [2]
2013 [2]
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Chemistry [1]
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Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC
期刊论文
NEUROPHARMACOLOGY, 2020, 卷号: 162, 页码: 13
作者:
Li, Qian
;
Zhang, Bing
;
Cao, Hang
;
Liu, Wei
;
Guo, Fei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
Oxytocin
mPFC
Dopamine
Antidepressant effect
Caffeic acid reduces A53T alpha-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease
期刊论文
PHARMACOLOGICAL RESEARCH, 2019, 卷号: 150, 页码: 14
作者:
Zhang, Yu
;
Wu, Qimei
;
Zhang, Lei
;
Wang, Qing
;
Yang, Zexian
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Caffeic acid
A53T
Parkinson's disease
Autophagy
JNK
Inhibition of Ezh2 In Vitro and the Decline of Ezh2 in Developing Midbrain Promote Dopaminergic Neurons Differentiation Through Modifying H3K27me3
期刊论文
STEM CELLS AND DEVELOPMENT, 2019, 卷号: 28, 期号: 10, 页码: 649-658
作者:
Hong, Feng
;
Zhao, Mengxue
;
Zhang, Lei
;
Feng, Linyin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
dopaminergic neurons
Ezh2
Nurr1
neural stem cells
Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson's Disease
期刊论文
MOLECULAR NEUROBIOLOGY, 2017, 卷号: 54, 期号: 9, 页码: 6970-6983
作者:
Wu, Qimei
;
Yang, Xiaoyu
;
Zhang, Lei
;
Zhang, Yu
;
Feng, Linyin
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
HDAC4
alpha-Synuclein
Neuroprotection
Parkinson's disease
PKC
Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways
期刊论文
Toxicology and applied pharmacology, 2017, 卷号: 319, 页码: 80-90
作者:
Cao, Qin
;
Qin, Liyue
;
Huang, Fei
;
Wang, Xiaoshuang
;
Yang, Liu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Chronic mild stress accelerates the progression of Parkinson's disease in A53T alpha-synuclein transgenic mice
期刊论文
EXPERIMENTAL NEUROLOGY, 2016, 卷号: 285, 页码: 61-71
作者:
Wu, Qimei
;
Yang, Xiaoyu
;
Zhang, Yu
;
Zhang, Lei
;
Feng, Linyin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Chronic mild stress
Parkinson's disease
alpha-synuclein
Dopamine
Microglia
Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants
期刊论文
EUROPEAN JOURNAL OF NEUROSCIENCE, 2014, 卷号: 40, 期号: 10, 页码: 3538-3547
作者:
Guo, Fei
;
Zhang, Qi
;
Zhang, Bing
;
Fu, Zhiwen
;
Wu, Bin
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
brain-derived neurotrophic factor
medial prefrontal cortex
mouse
ventral tegmental area
Targeting the Small- and Intermediate-Conductance Ca2+-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface
期刊论文
NEUROSIGNALS, 2014, 卷号: 22, 期号: 2, 页码: 65-78
作者:
Cui, Meng
;
Qin, Guangrong
;
Yu, Kunqian
;
Bowers, M. Scott
;
Zhang, Miao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Small- and intermediate-conductance Ca2+-activated potassium channels
Small-molecule positive modulators
Structure-based drug discovery
Ataxia
Alcohol use disorders
Parkinson's disease
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D-1, D-2 and serotonin 5-HT1A multi-action profile
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 4, 页码: 856-868
作者:
Sun, Haifeng
;
Zhu, Liyuan
;
Yang, Huicui
;
Qian, Wangke
;
Guo, Lin
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Asymmetric synthesis
Tetrahydroprotoberberines
Dopamine receptors
Serotonin receptors
Multi-action
New pharmacological profile
Targeting Epigenetics in Nervous System Disease
期刊论文
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2013, 卷号: 12, 期号: 1, 页码: 126-141
作者:
Zhang, Ruihan
;
Lu, Junyan
;
Kong, Xiangqian
;
Jin, Lu
;
Luo, Cheng
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
DNA methyltransferase
epigenetics
glioma
histone deacetylase
histone methyltransferase
nervous system disease
neurodevelopmental disease
neurodegenerative disease
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