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科研机构
上海药物研究所 [20]
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期刊论文 [19]
会议论文 [1]
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2018 [3]
2017 [2]
2015 [2]
2014 [3]
2012 [1]
2011 [2]
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A binding-block ion selective mechanism revealed by a Na/K selective channel
期刊论文
PROTEIN & CELL, 2018, 卷号: 9, 期号: 7, 页码: 629-639
作者:
Yu, Jie
;
Zhang, Bing
;
Zhang, Yixiao
;
Xu, Cong-qiao
;
Zhuo, Wei
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
cryo-EM
MscS
Na+/K+ selective channel
Solution structure of extracellular loop of human beta 4 subunit of BK channel and its biological implication on ChTX sensitivity
期刊论文
SCIENTIFIC REPORTS, 2018, 卷号: 8
作者:
Wang, Yanting
;
Lan, Wenxian
;
Yan, Zhenzhen
;
Gao, Jing
;
Liu, Xinlian
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2019/01/08
A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Bai, Fang
;
Pi, Xiaoping
;
Li, Ping
;
Zhou, Pingzheng
;
Yang, Huaiyu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
KCNQ2 potassium channel
hill equation
thermodynamic model
patch clamp electrophysiology
activators
Structural insights into the potency of SK channel positive modulators
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Nam, Young-Woo
;
Orfali, Razan
;
Liu, Tingting
;
Yu, Kunqian
;
Cui, Meng
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Identification of Intracellular beta-Barrel Residues Involved in Ion Selectivity in the Mechanosensitive Channel of Thermoanaerobacter tengcongensis
期刊论文
FRONTIERS IN PHYSIOLOGY, 2017, 卷号: 8
作者:
Song, Yingcai
;
Zhang, Bing
;
Guo, Fei
;
Yang, Maojun
;
Li, Yang
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  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
TtMscS
anion selectivity
beta-barrel
selective filter
patch-clamp
single mutation
High yield and efficient expression and purification of the human 5-HT3A receptor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 8, 页码: 1024-1032
作者:
Wu, Zhong-shan
;
Cui, Zhi-cheng
;
Cheng, Hao
;
Fan, Chen
;
Melcher, Karsten
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
human 5-HT3A receptor
BacMam
expression and purification
negative stain electron microscopy
receptor structure
High yield and efficient expression and purification of the human 5-HT_(3A) receptor
期刊论文
Acta Pharmacologica Sinica, 2015, 卷号: 36, 期号: 8, 页码: 1024
作者:
Wu Zhongshan
;
Cui Zhicheng
;
Cheng Hao
;
Fan Chen
;
Melcher Karsten
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2020/07/01
GATED ION-CHANNEL
CYS-LOOP RECEPTOR
X-RAY-STRUCTURE
STRUCTURAL BASIS
SYSTEM
PHARMACOLOGY
RECOGNITION
CONDUCTANCE
ANTAGONISTS
PREVENTION
human 5-HT3A receptor
BacMam
expression and purification
negative stain electron microscopy
receptor structure
The Human Ether-A-Go-Go-Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, 卷号: 351, 期号: 3, 页码: 596-604
作者:
Li, Ping
;
Chen, Xueqin
;
Zhang, Qiansen
;
Zheng, Yueming
;
Jiang, Hualiang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
β-Barrel Region Functions an Anion Selective Filter in MscS from Thermoanaerobacter tengcongensis
会议论文
作者:
Zhang B(张兵)
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Barrel Region Functions an Anion Selective Filter in MscS from Thermoanaerobacter tengcongensis
Targeting the Small- and Intermediate-Conductance Ca2+-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface
期刊论文
NEUROSIGNALS, 2014, 卷号: 22, 期号: 2, 页码: 65-78
作者:
Cui, Meng
;
Qin, Guangrong
;
Yu, Kunqian
;
Bowers, M. Scott
;
Zhang, Miao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Small- and intermediate-conductance Ca2+-activated potassium channels
Small-molecule positive modulators
Structure-based drug discovery
Ataxia
Alcohol use disorders
Parkinson's disease
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