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科研机构
上海药物研究所 [86]
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期刊论文 [84]
会议论文 [1]
学位论文 [1]
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2021 [5]
2020 [13]
2019 [5]
2018 [9]
2017 [3]
2016 [10]
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Chemistry [1]
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Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125
作者:
Zhang, Huimin
;
He, Jixiao
;
Hu, Guang
;
Zhu, Fei
;
Jiang, Hao
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/01/04
Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
期刊论文
PHARMACEUTICAL RESEARCH, 2021, 页码: 22
作者:
Han, Sifei
;
Mei, Lianghe
;
Quach, Tim
;
Porter, Chris
;
Trevaskis, Natalie
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04
conjugate
lipid
lymphatic
pharmacokinetics
prodrug
Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3204-3213
作者:
Zheng Zhang
;
Dai Chengqiu
;
Wu Honghong
;
Li Jingya
;
Nan Fajun
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/11/04
death associated apoptotic protein kinase 2
diabetes
alkylphenols
inhibitors
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan
期刊论文
CELL RESEARCH, 2021, 页码: 12
作者:
Ling, Shenglong
;
Shi, Pan
;
Liu, Sanling
;
Meng, Xianyu
;
Zhou, Yingxin
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer
期刊论文
ADVANCED SCIENCE, 2021, 页码: 12
作者:
Sun, Fang
;
Zhu, Qiurong
;
Li, Tianliang
;
Saeed, Madiha
;
Xu, Zhiai
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
glucose metabolism
immunogenic cell death
pancreatic cancer
photoimmunotherapy
prodrug nanoparticles
Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:
Zhang, Bin
;
Liao, Liping
;
Wu, Fan
;
Zhang, Fengcai
;
Sun, Zhongya
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
SMYD2 inhibitors
Thermal shift assay
Structure-activity relationships
Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 19, 页码: 10972-10983
作者:
Ma, Yuqin
;
Luo, Qichao
;
Fu, Jie
;
Che, Yanxin
;
Guo, Fei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/05/24
Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 10, 页码: 1966-1976
作者:
Zhao, Yuge
;
Yang, Yuting
;
Zhang, Jiaxin
;
Wang, Rong
;
Cheng, Biyun
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/24
Targeting delivery
Macrophages
Patchouli alcohol
Liposome
Inflammatory bowel disease
Colitis
SAF-189s, a potent new-generation ROS1 inhibitor, is active against crizotinib-resistant ROS1 mutant-driven tumors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7
作者:
Xia, Zong-jun
;
Ji, Yin-chun
;
Sun, De-qiao
;
Peng, Xia
;
Gao, Ying-lei
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2020/12/21
ROS1 kinase
ROS1 inhibitor
SAF-189s
lorlatinib
crizotinib resistance
G2032R mutant
NSCLC
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13
作者:
Wang, Zheng
;
Li, Zeng-xia
;
Zhao, Wen-cao
;
Huang, Hong-bo
;
Wang, Jia-qi
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/12/24
grincamycin B
marine natural product
isocitrate dehydrogenase 1
apoptosis
ER stress
intracellular ROS
Zebrafish embryos
hematological malignancies
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