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北京大学 [24]

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期刊论文 [22]

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浏览/检索结果: 共24条，第1-10条

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限定条件	专题：北京大学第一署名单位第一作者单位通讯作者单位

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	NF-kappa B signaling and cell-fate decision induced by a fast-dissociating tumor necrosis factor mutant 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017 Zhang, Xiaoling; Yin, Ning; Guo, Annan; Zhang, Qi; Zhang, Yalei; Xu, Youjun; Liu, Hongbo; Tang, Bo; Lai, Luhua 收藏 \| 浏览/下载：6/0 \| 提交时间：2017/12/03 NF-kappa B signaling dynamics TNF Receptor-ligand binding kinetics Gene expression Biased activation Apoptosis GENE-EXPRESSION DYNAMICS SPECIFICITY DETERMINES KINETICS ALPHA TNF
	Both piston-like and rotational motions are present in bacterial chemoreceptor signaling 期刊论文 scientific reports, 2015 Yu, Daqi; Ma, Xiaomin; Tu, Yuhai; Lai, Luhua 收藏 \| 浏览/下载：3/0 \| 提交时间：2015/11/13 LIGAND-BINDING DOMAIN COLI SERINE CHEMORECEPTOR ASPARTATE RECEPTOR ESCHERICHIA-COLI CONFORMATIONAL-CHANGES 3-DIMENSIONAL STRUCTURE SALMONELLA-TYPHIMURIUM CHEMOTAXIS RECEPTORS CROSS-LINKING PROTEINS
	Bacterial chemoreceptors and chemoeffectors 期刊论文 cellular and molecular life sciences, 2015 Bi, Shuangyu; Lai, Luhua 收藏 \| 浏览/下载：3/0 \| 提交时间：2015/11/11 Chemotactic response Receptor Ligand Molecular mechanism Receptor design COLI SERINE CHEMORECEPTOR LIGAND-BINDING DOMAIN DISULFIDE CROSS-LINKING ESCHERICHIA-COLI ASPARTATE RECEPTOR HAMP DOMAIN SIGNAL-TRANSDUCTION CHEMOTAXIS RECEPTOR MUTATIONAL ANALYSIS SENSORY ADAPTATION
	Protein-Protein Interface Analysis and Hot Spots Identification for Chemical Ligand Design 期刊论文 current pharmaceutical design, 2014 Chen, Jing; Ma, Xiaomin; Yuan, Yaxia; Pei, Jianfeng; Lai, Luhua 收藏 \| 浏览/下载：7/0 \| 提交时间：2015/11/13 Protein-protein interface analysis small molecular binder binding site detection ligandability hot spots Pocket V.3 SMALL-MOLECULE INHIBITORS DRUG DISCOVERY BINDING-SITES CONFORMATIONAL DYNAMICS STRUCTURAL BIOLOGY TRANSIENT POCKETS PREDICTION ALLOSTERY DRUGGABILITY MODULATION
	A comprehensive analysis of the influence of drug binding kinetics on drug action at molecular and systems levels 期刊论文分子生物系统, 2013 Yin, Ning; Pei, Jianfeng; Lai, Luhua 收藏 \| 浏览/下载：5/0 \| 提交时间：2015/11/10 HIV-1 PROTEASE INHIBITORS NF-KAPPA-B RESIDENCE TIME DISCOVERY MECHANISMS TRANSIENT DYNAMICS ONSET
	Computational Design of Helical Peptides Targeting TNF alpha 期刊论文 angewandte chemie international edition, 2013 Zhang, Changsheng; Shen, Qi; Tang, Bo; Lai, Luhua 收藏 \| 浏览/下载：3/0 \| 提交时间：2015/11/10 computational design helical peptides protein peptide drug protein-protein interactions TNF NECROSIS-FACTOR-ALPHA CRYSTAL-STRUCTURE RECEPTOR-BINDING SEQUENCE PROTEINS AFFINITY
	Automatch: Target-binding protein design and enzyme design by automatic pinpointing potential active sites in available protein scaffolds 期刊论文 proteins structure function and bioinformatics, 2012 Zhang, Changsheng; Lai, Luhua 收藏 \| 浏览/下载：3/0 \| 提交时间：2015/11/10 active sites matching enzyme design target-binding protein design backbone flexibility active site recapitulation COMPUTATIONAL DESIGN HOT-SPOTS HIV-1 GP120 MECHANISTIC IMPLICATIONS CRYSTAL-STRUCTURES INTERFACE SUBSTRATE EVOLUTION RECEPTOR DATABASE
	Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta-cells 期刊论文 american journal of physiology cell physiology, 2012 Dou, Hai-Qiang; Xu, Yun-Fei; Sun, Jin-Peng; Shang, Shujiang; Guo, Shu; Zheng, Liang-Hong; Chen, Chao-chao; Bruce, Iain C.; Yu, Xiao; Zhou, Zhuan 收藏 \| 浏览/下载：9/0 \| 提交时间：2015/11/13 inositol 1,4,5-trisphosphate PATCH-CLAMP TECHNIQUES INTRACELLULAR CA2+ GLUCOSE-TOLERANCE K+ CHANNELS ANESTHESIA RECEPTOR CURRENTS ISLET EXOCYTOSIS KETAMINE
	Towards structure-based protein drug design 期刊论文生物化学会汇刊, 2011 Zhang, Changsheng; Lai, Luhua 收藏 \| 浏览/下载：7/0 \| 提交时间：2015/11/13 computational design de nova design grafting protein drug protein-protein docking protein therapeutic COMPUTATIONAL DESIGN ANTIBODY THERAPY HOT-SPOTS INTERFACE DISCOVERY PAIR THERAPEUTICS POTENTIALS RESIDUES CANCER
	Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching 期刊论文 journal of medicinal chemistry, 2008 Wei, Dengguo; Jiang, Xiaolu; Zhou, Lu; Chen, Jing; Chen, Zheng; He, Chong; Yang, Kun; Liu, Ying; Pei, Jianfeng; Lai, Luhua 收藏 \| 浏览/下载：2/0 \| 提交时间：2015/11/10 LEUKOTRIENE A(4) HYDROLASE DESIGNED MULTIPLE LIGANDS TIGHT-BINDING INHIBITORS NMDA RECEPTOR ANTAGONIST DRUG DISCOVERY POTENT INHIBITORS LTA(4) HYDROLASE LOW-AFFINITY NETWORK ANALOGS

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