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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 内容类型：期刊论文     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation 期刊论文 CELLULAR AND MOLECULAR LIFE SCIENCES, 2017 Liu, Junjun; Zhang, Chuanmao 收藏  |  浏览/下载：39/0  |  提交时间：2017/12/03 Polo-like kinase 1  Mitosis  Usp16  Kinetochore  Cullin 3  E3 ligase  POLO-LIKE KINASES  KINETOCHORE-MICROTUBULE DYNAMICS  SPINDLE ASSEMBLY CHECKPOINT  PROPER CHROMOSOME SEGREGATION  CELL-DIVISION  BOX DOMAIN  PROTEIN  PHOSPHORYLATION  STABILITY  COMPLEX   Designed inhibitor for nuclear localization signal of polo-like kinase 1 induces mitotic arrest 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017 Chen, Fangjin; Zhuo, Xiaolong; Qin, Tan; Guo, Xiao; Zhang, Chuanmao; Lai, Luhua 收藏  |  浏览/下载：10/0  |  提交时间：2017/12/03 anticancer  mitotic arrest  nuclear localization signal  Plk1 inhibitor  polo-like kinase 1  BOX DOMAIN  CANCER-THERAPY  CENTROSOME MATURATION  PLK1  PHOSPHORYLATION  AURORA  MITOSIS  ENTRY   Identification of nitroimidazole-oxime derivatives targeting the polo-box domain of polo-like kinase 1 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 24, 页码: 6581-6588 作者:  Sun, Juan;  Liu, Han-Yu;  Xu, Ruo-Fei;  Zhu, Hai-Liang 收藏  |  浏览/下载：10/0  |  提交时间：2019/12/12 Nitroimidazole-oxime  PLK1-PBD  Antitumor  Molecular docking   Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain 期刊论文 2017, 卷号: 8, 期号: 1, 页码: 1234-1246 作者:  Chen, Yunyu;  Zhang, Jing;  Li, Dongsheng;  Jiang, Jiandong;  Wang, Yanchang 收藏  |  浏览/下载：3/0  |  提交时间：2020/01/03 Polo-like kinase 1 inhibitor  Polo-Box domain  fluorescence polarization  protein-protein interactions  cancer therapy   Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase1 期刊论文 CHEMMEDCHEM, 2016 Yun, Taikangxiang; Qin, Tan; Liu, Ying; Lai, Luhua 收藏  |  浏览/下载：3/0  |  提交时间：2017/12/03 inhibitors  kinase domain  non-ATP binding site  polo-like kinase1  virtual screening  1 PLK1 INHIBITORS  P38 MAP KINASE  CANCER-THERAPY  BINDING-SITE  BOX DOMAIN  PROTEIN  POLO-LIKE-KINASE-1  IDENTIFICATION  APOPTOSIS  DESIGN   Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016 Yun, Taikangxiang; Qin, Tan; Liu, Ying; Lai, Luhua 收藏  |  浏览/下载：4/0  |  提交时间：2017/12/04 Polo-like kinase 1  Polo-box domain  Small molecular inhibitor  Halogenosulfamoylphenyl acylthiourea  Binding affinity  In vitro assay  POLO-LIKE KINASE  INDUCE MITOTIC ARREST  BOX DOMAIN  PROGNOSTIC-SIGNIFICANCE  CANCER-CELLS  TUMOR-CELLS  DRUG DESIGN  EXPRESSION  DISCOVERY  DOCKING   Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2016 Qin, Tan; Chen, Fangjin; Zhuo, Xiaolong; Guo, Xiao; Yun, Taikangxiang; Liu, Ying; Zhang, Chuanmao; Lai, Luhua 收藏  |  浏览/下载：3/0  |  提交时间：2017/12/04 ADVANCED SOLID MALIGNANCIES  GROWTH IN-VIVO  PHASE-I  CELLULAR UPTAKE  PLK1  POLO-LIKE-KINASE-1  CANCER  PHOSPHOPEPTIDES  IDENTIFICATION  RECOGNITION   PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry 期刊论文 journal of cell science, 2013 Wang, Gang; Chen, Qiang; Zhang, Xiaoyan; Zhang, Boyan; Zhuo, Xiaolong; Liu, Junjun; Jiang, Qing; Zhang, Chuanmao 收藏  |  浏览/下载：38/0  |  提交时间：2015/11/13 PCM1  Plk1  Primary cilium  POLO-LIKE KINASE  CELL-CYCLE PROGRESSION  INTRAFLAGELLAR TRANSPORT  MICROTUBULE NUCLEATION  BOX DOMAIN  AURORA-A  CENTROSOME  COMPLEX  PHOSPHORYLATION  LOCALIZATION   The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation 期刊论文 ACTA PHARMACOLOGICA SINICA, 2009, 卷号: 30, 期号: 10, 页码: 1443-1453 作者:  Li, Li;  Wang, Xu;  Chen, Jing;  Ding, Hong;  Zhang, Yu 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 antitumor drugs  Aristolactam AIIIa  Polo-box domain  Polo-like kinase 1 inhibitor